Med chem quiz 10

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75ford
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187618
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Med chem quiz 10
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2012-12-06 18:27:48
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Med chem quiz 10
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Med chem quiz 10
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  1. Egrifta
    Treat Lipodystrophy in HIV patients
  2. Didanosine/Videx
    • NRTI
    • Acid labile, dont take with fruit juice
    • Peripheral neuropathy, pancreatitis
    • Very potent
  3. Lamivudine/Epivir
    • NRTI
    • Well tolerated
    • Drug inter with Bactrim
  4. Stavudine/Zerit
    • NRTI
    • Dose based on weight
    • Contra. with Retrovir
  5. Abacavir/Ziagen
    • NRTI
    • Very potent but not well tolerated
    • Watch for Steven Johnson's
  6. Zalcitabine/Hivid
    • NRTI
    • Very weak drug
    • With or without food
  7. Zibovudine/Retrovir
    • First NRTI
    • Initial treatment will cause flu-like symp
    • Drug interactions that increase bone marrow tox
  8. Emtricitabine/Emtriva
    • NRTI New 2003
    • Pediatric use
    • better absorbed due to a hallogen
  9. Efavirenz/Sustiva
    • NNRTI
    • Has slower resistance
    • Teratogen
    • 1/2 pt's will have CNS side effects
  10. Nevirapine/Viramune
    • NNRTI
    • Effective but can lead to Steven J and fatal hepatitis
  11. Delaviridine/Rescriptor
    • NNRTI
    • 4 tabs TID (bad pt compl)
    • Sulfa allergy
  12. Etravirine/Intelence
    • NNRTI
    • Do not use with other NNRTI
    • Take with ritonavir to help with 3A4 met.
  13. Rilpivirine/Endurant
    • NNRTI
    • Long 1/2 life
    • QT elongation
  14. Tenofovir/Viread
    • Nucleotide analog RTI (NARTI)
    • Phosphate prodrug
    • Take with high fat meal****
    • Once daily dose
  15. Saquinavir/Invirase
    • Protease inhibitor (PI) First
    • Poorly tolerated due to flu
    • Can cause arrhythmias
    • High Fat meal***
    • caution in hemophiliacs
  16. Idinavir/Crixivan
    • PI
    • Severe diet restrictions (no food)
    • Watch for kidney stones
    • Must stay in original cont.
  17. Ritonavir/Norvir
    • PI (most potent)
    • Has worst side effects
    • Used for positive drug interactions
  18. Neifinavir/Viracept
    • PI
    • Not very potent
  19. Amprenavir/Agenerase
    • PI
    • Sulfa allergy
    • Many big Pills
    • No Vit E suppl***
  20. Fosamprenavir/Lexiva
    • PI
    • Prodrug of Amprenaivr
    • Increases water solubility
  21. Lopinavir and Ritonavir/Kaletra
    • PI
    • Combo drug that uses positive drug interaction
  22. Atazanavir/Reyataz
    • PI (azapeptide inhibitor)
    • Competative inhibitor of natural subst.
    • will react with statins due to glucoronidation
  23. Tipranavir/Aptivus
    • PI (NON-peptide based)
    • The idea was to have less side effects
    • Refrigerate
    • Must be taken with Ritonavir
  24. Duranavir/Prezista
    • PI (NON-peptide based)
    • Take with food***
    • Take with Ritonavir
    • Watch for diabetes
  25. Enfuvirtide/Fuzeon
    • HIV entry inhibitor
    • Prevents fusion and entry of Viral RNA
  26. Maraviroc/Selzentry
    • Chemokine receptor antagonist
    • Must have Tropism testing
    • 40% of pt will develop mutation and resistance
  27. Raltegravir/Isentress
    • INSTI Integrase Strand Transfer Inhibitor
    • Blocks integrase enzyme required for insertion of Viral DNA
    • Watch for Creatinine Kinase and Rhabdo
  28. Gardasil
    • HPV vaccine
    • Type 16 and 18 HPV lead to most cervical cancer.
  29. Carvarix
    HPV prophylaxis

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