MODA DRUGS (4)

Card Set Information

Author:
yl456
ID:
187971
Filename:
MODA DRUGS (4)
Updated:
2013-03-26 12:40:09
Tags:
Antihelmintics
Folders:

Description:
Mechanism and Effect
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user yl456 on FreezingBlue Flashcards. What would you like to do?


  1. Amino-Acetonitrile Derivatives
    • Active against nematodes
    • Agonist, acts on nematode specific Ach receptor subunit
    • Causes paralysis
  2. Benzimidazole
    • Inhibits tubulin polymerisation
    • Deplete energy reserves
    • Inhibit waste excretion
    • Inhibit secretion of protection factors
    • Effective against adults, larvae and eggs
  3. Thiabendazole
    Benzimidazole
  4. Fenbendazole
    Benzimidazole
  5. Cyclooctadepsipeptide
    • Against nematodes and filaria
    • For use in dogs and cats
    • Causes hyperpolarisation and flaccid paralysis
    • Intereferes with locomotion, feeding and reproduction
  6. Emodepside
    • Cyclooctadepsipeptide
    • Forms pore inducing Ca2+ entry
    • Interacts with lat-1 and lat-2
    • StimulateS SLO-1
    • Functions as ionophore
  7. Cysteine Proteases
    • Derived from plants
    • Resistant to acid digestion
    • Attack helminth cuticle
    • Kill/reduce egg production
    • Cysteine residue hydrolyses peptide bond of helminth proteins
  8. Imidazothiazoles
    • Cholinergic agonists
    • Against GI helminths and lungworms
    • Cause depolarisation, muscle contraction and spastic paralysis
  9. Levamisole
    • Imidazothiazole
    • Water-soluble
    • More selective for nematode receptor than mammalian
    • Lowest open channel blockade characteristics
  10. Macrocyclic lactones
    • Increase Cl- permeability
    • Cause depolarisation and flaccid paralysis
    • Very potent
    • For nematodes and ectoparasites
    • Probably glutamate gated but may be GABA
  11. Avermectins eg. Ivermectin
    • Macrocyclic lactone
    • Most action on alpha subunits
    • Potentiate effects of endogenous glutamate at low conc
    • Open channels directly at high conc
    • Not suitable for Collies as┬ámutated mdr-1 gene
    • Nematodes and arthropods
  12. Organophosphates and carbamates
    • Cholinesterase inhibitors
    • Also insecticides
    • React with serine residue of active site
    • Result in spastic paralysis
  13. Dichlorvos
    Organophosphate
  14. Aldicarb
    Carbamate
  15. Piperazine
    • GABA agonist for nematodes
    • Acts on ligand gated Cl- channels
    • Causes muscle hyperpolarisaton
    • Flaccid paralysis
    • Low charge so can access receptors
    • Inhibits succinate production and depletes ATP
  16. Praziquantel
    • Active against cestodes
    • Rapidly absorbed from gut then re-secreted
    • Increases Ca2+ permeability
    • Causes rapid muscle contraction and spastic paralysis
    • Causes tegument damage and vacuolisation
  17. Salicylanilide
    • Proton ionophore for flukes
    • Uncoupler of oxidative phosphorylation
    • Lipophilic
    • Cause fall in tegument pH, leads to decreased motility and depleted ATP
  18. Tetrahydropyrimidine
    • Nicotinic agonist
    • Causes depolarisation, muscile contraction and spastic paralysis
  19. Pyrantel
    • Tetrahydropyrimidine
    • Must be kept out of direct sunlight
    • Causes open channel block at lowest concentration
    • Insoluble
    • Oral delivery minimises toxic side effects
  20. Triclabendazole
    • Type of benzimidazole
    • Selective against flukes
    • Resistance is increasing

What would you like to do?

Home > Flashcards > Print Preview