Glucokinase vs. Hexokinase?
- What is important about glucokinase's Vmax?
Glucokinase has higher km (specificity) and higher capacity to process glucose
Glucokinase is found in the liver while hexokinase is found in most tissues.Activated by glucose
Glucokinase has a high Vmax, allowing liver to remove lots of glucose from blood post-prandially to prevent hyperglycemia.
Glucokinase has absolutely no feedback inhibition, while hexokinase is allosterically inhibited by G6P (fastest regulation).