Moos - RA and Gout

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Author:
Spykenard
ID:
188877
Filename:
Moos - RA and Gout
Updated:
2012-12-11 21:04:12
Tags:
Pharmacology
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Description:
RA and Gout
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  1. What is a DMARD?
    Disease Modifying Anti-Rheumatic Drug
  2. What is a BRM?
    Biologic Response Modifier
  3. In addition to NSAIDs, glucocorticoids are also used for symptomatic relief of RA.  Name three of these glucocorticoids.
    • Dexamethasone
    • Prednisone
    • Hydrocortisone
  4. The more potent than NSAID glucocorticoids inhibit what?
    They inhibit cytokine production and response
  5. What are some acute effects of glucocorticoids?
    • GI ulceration and hemorrhage
    • Impaired resistance to infection
    • SUPERINFECTIOn
  6. What are some chronic effects of glucocorticoids?
    • Adrenal supression
    • Cushing's syndrome
    • Electrolyte imbalance
    • Weight gain
    • Facial puffiness
    • Osteoporosis
    • Thinning of the skin
    • Easy bruising
    • Cataracts
    • Risk of Infection
    • Muscle wasting
  7. What do DMARDs do?
    Slow or stop the progression of RA without treating the symptoms.  These drugs can be toxic and require constant patient monitoring
  8. Name 3 DMARDs.
    • Cytotoxic - Methotrexate
    • Leflunomide (Arava)
    • Older Agents - sulfasalazine, hydroxychloroquine, minocycline

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