Moos - RA and Gout
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What is a DMARD?
Disease Modifying Anti-Rheumatic Drug
What is a BRM?
Biologic Response Modifier
In addition to NSAIDs, glucocorticoids are also used for symptomatic relief of RA. Name three of these glucocorticoids.
The more potent than NSAID glucocorticoids inhibit what?
They inhibit cytokine production and response
What are some acute effects of glucocorticoids?
- GI ulceration and hemorrhage
- Impaired resistance to infection
What are some chronic effects of glucocorticoids?
- Adrenal supression
- Cushing's syndrome
- Electrolyte imbalance
- Weight gain
- Facial puffiness
- Thinning of the skin
- Easy bruising
- Risk of Infection
- Muscle wasting
What do DMARDs do?
Slow or stop the progression of RA without treating the symptoms. These drugs can be toxic and require constant patient monitoring
Name 3 DMARDs.
- Cytotoxic - Methotrexate
- Leflunomide (Arava)
- Older Agents - sulfasalazine, hydroxychloroquine, minocycline
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