What are the 5 types of apolipoproteins? Where is each found? What is their function?
- ApoB100 (VLDL, IDL, LDL) - Structural protein for VLDL, ligand for LDL receptor
- ApoB48 (Chylomicrons & chyloremnants) structural protein - lacks LDL-R binding domain so depends on ApoE for LDL-R binding.
(chylo, VLDL, IDL, HDL, chylo remnants) Ligand for binding IDL and VLDL to LDL-R and LRP (LDL-related R protein).
- HDL, chylomicrons - activates LCAT & is structural protein of HDL
(chylos, VLDL, IDL, HDL) activates LPL. Insuiln promotes synthesis of ApoCII. LPL degrades TAGs in lipoproteins into FAs.