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What medication is associated with polycystic ovarian syndrome?
What 4 AEDs cause weight gain?
What medication is associated with difficulty word finding?
What are 4 common AEs associated with almost all anti-epileptic drugs?
What adverse event basically killed the advancement of felbamate?
- Aplastic anemia [usually presents in the first 6 months]
- Hepatic failure
What is a serious life threatening AE associated with lamotrigine and valproic acid?
- Severe rash [Toxic Epidermal Necrolysis - rapid titration increases risk - more common in some Asian populations]
- Stevens-Johnson Syndrome
What is the indication for ACTH (Acthar)?
Monotherapy for infantile spasms in children aged 2 or younger
What can happen during ACTH withdrawal?
- Cushing's Syndrome
- Adrenal Insufficiency
What are some common side effects of ACTH?
- Fluid retention
- Altered glucose intolerance
- Elevated BP
- Behavioral and Mood changes
- Increased appetite and weight gain
What are the indications for carbamazepine (Tegretol)?
- Partial (Simple and Complex)
- Primary and Secondary Generalized Tonic-Clonic
What are some side effects of carbamazepine?
- Blurred vision
- Cognitive impairment
- Stevens-Johnson syndrome
- Aplastic anemia
What drug may aggravate spike wave seizures?
What is the main indication for ethosuxamide (Zarontin)?
What are some side effects of ethosuxamide?
- Blood dyscrasia
This drug for uncomplicated absence as a NARROW therapeutic spectrum. It is _____.
This drug that results in urinary retention and poor compliance because of TID dosing is indicated as an add-on treatment of partial seizures in patients 18 years of age and older. It is _____.
This broad spectrum AED has not been very successful due to its adverse event profile. It is _____.
The most common complaint of _____ is dizziness, and is often seen with an increase in diplopia and ataxia when added to carbamazepine.
The most toxic adverse event, which is _____, of lamotrigine can often be overcome by slow dose titration.
Rash [higher incidence in children and those receiving it in combination with valproate]
What is the serious side effect of the CYP 3A4 inducer, Oxcarbazepine (Trileptal)?
Families and caregivers of patients receiving _____ should be counseled to monitor for the emergence of anger, aggression, hostility, unusual changes in mood, personality, or behavior.
This inexpensive and broad spectrum AED has long term cognitive and behavioral effects, is a strong inducer, and can precipitate spike wave seizures. It is _____.
This AED drug exhibits zero-order kinetics at high doses and may aggravate or precipitate generalized absence spike-wave seizures.
What are the non-dose-related AEs associated with phenytoin? (7)
- Coarsening of facial features
- Worsening of acne
- Gingival hyperplasia
- Folate deficiency anemia
This AED is often associated with weight gain and worsening generalized absence spike-wave seizures. It is indicated for complex partial seizures.
This drug often show weight loss in patients, which can be beneficial, but is also associated with open-angle glaucoma and increased metabolism of estrogen.
This broad spectrum AED is associated with neural tube defects and weight gain. It is contraindicated in patients with hepatic impairment and can show Reye-like symptoms.
Valproic acid (Depakene, Depakote)
What is the black box warning on Vigabatrin?
Visual field constriction
Name 4 of the 8 broad spectrum AEDs.
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