Final Lipids (1)

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Final Lipids (1)
2012-12-14 02:46:02

FA synthesis, TAG synthesis, B-oxidation
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  1. Where does FA synthesis take place? (3) What are its two mian functions? (2)
    FA synthesis mostly takes place in liver, lactating mammary glands, and to a lesser extent in adipose tissue.

    • 1. Energy - oxidized by many tissues (esp liver & muscle) for energy. TAGs = main source of energy.
    • 2. Structural - found in membrane, precursor to prostaglandins
  2. Where does FA synthesis take place? (3) What are its two mian functions? (2)
  3. What are its two regulatory enzymes? (FA syn)
    ACC and FAS 

    ACC is activated by citrate, ATP, insulin & inhibited by LC FA CoA, AMPK

    Both activated by high carb/high calorie diets. Both inactivated by low calorie/fasting/high fat diet. 
  4. Mammals only have which desaturases from carboxyl end?
    4,5,6, 9

    We don't have w-3 or w-6
  5. Role of PUFAs? W6 vs. W3?
    - Eicosanoids made from w3 PUFA may protect against effects of thromboxanes by preventing platelet aggregation and competition decreasing w6 containing eicosanoids (more harmful). 
  6. What is the relationship between ALA, EPA and DHA?
    ALA (precursor 18:3w3) --> EPA (20:5 w3) --> DHA(22:6 w3)
  7. Where are lipid droplets found? Where are they found in muscle?
    In almost every cell. 

    Close to mitochondria to provide energy via B-oxidation. 
  8. What are the substrates for TAG synthesis? Where do they come from?
    Glycerol 3 P and 3 LC FA CoAs. 

    Glycerol3P is from DHAP (glycolysis), from glycerol via glycerol kinase, or from dietary TAG (2-MAG)
  9. What can happen to a fatty acid?
    Can be used for TAG synthesis or oxidized for energy.