How does insulin affect carbohydrate metabolism?
What tissues are affected the most?
Liver, muscle, adipose tissue.
1. Glycogenesis in liver & muscle: Activates PP1 which destroys cAMP and activates glycogen synthase.
2. Increase in glucose uptake in muscle & tissue via GLUT 4: Insulin activates GLUT 4 transporters --> glycerol 3P for fat synthesis.