Podiatry Boards Part 2

Card Set Information

Author:
dhubbard
ID:
189505
Filename:
Podiatry Boards Part 2
Updated:
2012-12-14 14:11:51
Tags:
Antibiotics Presby
Folders:

Description:
Antibiotics
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user dhubbard on FreezingBlue Flashcards. What would you like to do?


  1. What is the MOA of penicillins?
    • Inhibit cell wall synthesis
    • Bacterialcidal
  2. Which class of penicillins can be used for anaerobes?
    • Natural penicllin
    • Penicillin G and V
  3. What penicillins can be used for psuedo?
    Pipercilin, ticarcillin, mezlocillin
  4. What are the penicillins with a beta lactamase inhibitor?
    • Timentin- ticarcillin/clavulanic acid= 3.1 gm IV q4-6
    • Zosyn- pipercillin/tazobactam= 3.375 gm IV q8
    • Unasyn- ampicillin/sulbactam= 1.5-3.0 gm IV q6
    • Augmentin- amoxicillin/clavulanic acid= 875 mg PO bid
  5. Which penicillin can increase BP by increasing Na?
    Ticarcillin
  6. What is the MOA of cephalosporins?
    • Inhibit cell wall synthesis
    • Bacterialcidal
  7. What is the spectrum of activity?
    • 1st- gram + and little gram - (PESS)
    • 2nd- more gram - and gram + (-) are HeN PECK
    • 3rd- More gram - including psuedo
    • 4th- greatest gram - (Cefipime= Maxipime)
  8. What is the cross reactivity with penicillins?
    • Some say 1-5%
    • Presby 5-15%
  9. This is the gorillacillin and is also a beta lactam?
    Imipenem/cilastatin (Primaxin)
  10. Is Aztreonam a beta lactam?
    • Yes
    • Only for gram -
  11. What is the MOA of quinolones?
    • Inhibit DNA gyrase
    • bacterial cidal
  12. What is the only quinolone that may cover CA MRSA?
    • Cipro 250-500 mg PO
    • 200-400mg IV
  13. What are the contras of quinolones?
    • Don't take with milk or calcium, vitamin D
    • Caution with tendons and bone
    • Don't give to kids it can damage the cartilage
  14. What is the MOA of AMG?
    • Binds 30S bacterial ribosome inhibits protein synthesis
    • Tobramycin, Gentamycin, Amikacin
  15. When do you check troughs and peaks of AMGs?
    Check after 3rd dose
  16. What are the ADRs of AMGs?
    • ototoxcity
    • nephrotoxcity
    • neuromusclar blockage
  17. What is the MOA of Sulfonamide-Trimethoprim Sulfamethoxazole?
    • Bactrim
    • Sulfamethoxazole- inhibits folic acid production
    • Trimethoprim- inhibits bacterial dihydrofolate reductase
    • bacteriostatic
  18. What is the dosing of Bactrim?
    • Trimethoprim= 160mg
    • Sulfamethoxazole= 800mg
  19. ADRs of bactrim?
    • Hemolytic anemia
    • Contra with oral hypoglycemics and G6PD deficiency
  20. What is the MOA of Macrolids?
    • Bind 50s bacterial ribosome inhbitis protein synthesis
    • bacteriostatic
    • Mainly gram positive staph and strept
  21. What are teh drugs?
    • Erythromycin= 250-500 mg PO QD
    • Azithromycin (Zpack)= 500mg 1st day 250 mg qd for 4 days
    • Clarithromycin= 250 mg po bid
    • Dirythromycin
  22. What is the MOA of vanco?
    • Inhibit cell wall synthesis
    • bactericidal
    • 1gram IV q12hr
    • 125 mg PO qd for Cdiff
  23. What are the peaks and troughs of Vanco?
    • Peak= 15-30 mg/ml (30min after 3rd dose)
    • Trough= <10 mg/ml (30 min before 4th dose)
    • (Presby says after 5th dose)
  24. Spectrum of Vanco?
    • MRSA (HA)
    • Staph, strept
    • + anaerobes (Clostridium and Cornybacterium)
    • Not active against gram -
  25. ADRs of vanco?
    • Red man
    • Nephro
    • Ototoxcity
  26. What is the MOA of Clindamycin?
    • Inhibits translation of 50s bacterial ribosome
    • bacteriostatic
  27. ADRs of clinda?
    • PSUEDOMEMBRANOUS COLITS!!!!
    • C. diff
  28. What abx can stain bones and teeth?
    • Tetras
    • Minocycline= 100mg PO q12-14
    • Doxycycline= 100mg po q12-24
    • tetracycline= 250-500mg PO qid
  29. This abx is used for TB and changes body fluids orange?
    Rifampin
  30. This is used for ANAEROBES gram -?
    • Flagyl (Metronidazole) use in C.diff
    • 500mg PO tid
  31. What drug can cause a metal taste?
    Flagyl
  32. When do you want to surgical prophylax a pt?
    • >2 hr surgery
    • Implants
    • trauma
    • immunocompromise
    • SBE risks
  33. What are the common abx for prophylaxis?
    • Ancef (Cefazolin) 1 gram IV
    • Clindamycin 600mg IV
    • Vancomycin 1 gram IV
  34. What are the HA MRSA abx?
    • VCSZ
    • Vanco
    • Cubicin
    • Synercid
    • Zyvox (Linezolid)
  35. What are the abx for CA MRSA?
    • M BCD
    • Minocycline
    • Bactrim
    • Cipro
    • Doxy
  36. What are the abx that are PO for MRSA?
    • Linezolid
    • Mino
    • Cipro
    • Bactrim
  37. What are teh Psuedomonas abx?
    • A Man Can't Fire Pelo Z
    • Atreonam
    • Maxipime
    • Cipro
    • Fortaz
    • Pipercillin
    • Zosyn
  38. What are the Broad Spectrum abx?
    • D TAAZ
    • Doripenem
    • Timentin
    • Augmentin
    • Alveox
    • Zosyn
  39. Your pt gets C. diff what do you do?
    • Stop abx
    • NO ANTIDIARRHEAL MEDS!!!!!!! (They allow toxins to collected)
    • Fluid and electrolyte balance
    • ABX: Metronidazole 500 mg q8
    • or Vanco 125 mg PO q6
  40. What are your Polyenes for fungal meds and what is the MOA?
    • Nystatin
    • Amphotericin B
    • MOA: binds ergosterol (hole in membrane)
    • fungistatic
  41. What is the MOA of Azoles?
    Inhibit ergosterol also and increase intracellular peroxide levelsĀ 
  42. Azoles may interact with what major meds?
    • Increase warfarin, cyclosporin, theophyline, oral hypoglycemics, rifampin
    • Inhibits phenytoin metabolism
  43. Which azole is good for yeast infections?
    Clotrimazole
  44. What meds and allylamines?
    • Terbinafine and Naftifine
    • MOA: Inhibits squalene epoxidase
    • FUNGICIDAL
  45. Does of Lamisil?
    • Onychomycosis: 250 mg/day for 12 weeks
    • Tinea pedis: 250mg/day for 2-6 weeks
  46. What do you look for in a liver function test for Lamisil?
    • ALP, ALK levels andĀ 
    • Kidney Cr<50ml/min
  47. What med increases clearnace of Lamisil?
    Rifampin
  48. What med decreases clearance of lamisil?
    Cimetidine
  49. What fungistatic med inhibits cell mitosis?
    Griseofulvin
  50. What other fungal drug inhibits squalene epoxidase?
    Tolnaftate
  51. What is whitfields ointment?
    Benzoic acid and salicyclic acid that causes desquamation of epidermis containing fungal organisms

What would you like to do?

Home > Flashcards > Print Preview