Podiatry Boards Part 2

Card Set Information

Author:
dhubbard
ID:
189506
Filename:
Podiatry Boards Part 2
Updated:
2012-12-14 14:23:25
Tags:
Anesthetics Locals
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Description:
Local Anesthetics
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  1. What is the MOA of local anesthetics?
    Bind Na channel in nerves and block depolarization
  2. What does lipid solubility do for locals?
    Penetrate nerve membrane and have greater potency
  3. What does protein binding do for locals?
    • influences duration of action
    • agents of short duration bind poorly
  4. pKa and pH?
    • As pH decreases equilibrium shifts toward cation with binds to receptor.
    • pKa defines the pH at which the base and cation forms are equal
    • Agents with a pKa closer to tissue pH have a rapid onset
  5. Locals cause dialation why is this good?
    more vascular absoprtion less local
  6. Amides are what and metabolized where?
    • Locals that have 2 "i"s
    • Metabolized in the liver
  7. What agent is used in epidurals?
    Bupivicaine and Mepivacaine
  8. What amide really blocks motor control?
    Etidocaine
  9. What are signs of CNS toxicity?
    • Ringing in the ears
    • Light headed
    • Confusion
    • Tonic-clonic convulsions
    • Unconsciousness
    • General CNS depression
    • Respiratory arrest
  10. What are signs of cardio toxicity?
    • HTN
    • Tachycardic
    • Later bradycardic
    • arrythmias
    • circulatory collapse
    • decreased CO
  11. What does infection do to local?
    Decreases its effectivty

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