Human Immunodeficiency type I
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Established routs of transmission
Blood; unprotect sexual intercourse; perinatal infection
structure of the HIV virus
spherical envelope (gp120/41); nucleocapsid (2 ss+RNA; RT; IN).
Components of viral genome
pol; env; gag; LTR
What do each viral genome (pol; env; gag; LTR) encode
pol-RT;IN; and protease. env-gp120/41. gag(nuceleocapsid; matrix pro). LTR (regulatory)
Sequence of viral life cycle
BRITA-B; Binding-reverse transcription-integration-trascripion/translation-assembly-budding
surface receptors utilized by hiv
CD4 CCR5 CXCR4
three phases of infection; symptoms
acute(viremia); latency (asymptomatic); symptomatic (viral load increase; CD4 T cell decline)
lymphadonopathy; fever; infections; malignancies; wasting; dementia
AIDS definning diseases (infectious)
Kaposi's sarcoma; pneumocystics pneumonia; mycobacterium avium-intracellular complex; CMV disease
macrophages serve as carriers to the brain; results in HIV associated dementia.
mechanism of cell killing by HIV
toxic DNA; budding damages cell permeability; syncytia formation; induction of apoptosis
population based stratigies to reduce HIV transmission
education about transmission; risks; blood screening; prevent accidental exposure
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