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Low potency antipsychotropic agents tend to have less/more anticholinergic effects, hypotension and sedation in comparison to high potency agents.
More anticholinergics effects, hypotension and sedation
High potency first generation antipsychotics (FGAs) are associated with lower/higher rate of EPS when compared to low potency agents.
Higher rates of EPS
Dystonic reactions typically occur by the ___ day of antipsychotic treatment.
Dystonic reactions include ____.
Abruptly occurring spasms, most commonly those of the head and neck.
Acute dystonic reactions can be treated with IV/IM (oral not recommended) ____ or ____.
- Diphenhydramine 50mg, or
- Benztropine 2mg
Akathisia usually occurs within ____ weeks of new antipsychotic therapy.
Akathisia reactions include ____.
- Inner restlessness
- Desire to move for the sake of moving
Akathisiamay respond to treatment with ____ or ____.
- Beta-blockers, or
- (Or dose reduction, medication change)
Parkinsonism is characterized by ____.
- Akinesia (loss of arm swing when walking, loss of facial expression)
Parkinsonism usually occurs within ____ weeks after antipsychotic initiation.
Treatment of parkinsonism primarily involves ____ agents.
Tardive dyskinesia symptoms include ____.
- Abnormal involuntary movements
- Hypermobility of facial muscles and extremities
- Lip smacking
- Tongue thrusting
The primary intervention for tardive dyskinesia is ____.
Discontinue the offending agent
Hallmarks of neuromuscular syndrome (NMS) are ____.
- High fever
- Muscle rigidity
Treatment for NMS includes ____.
- Discontinuation of the drug
- Supportive measures
- Drug therapy, including dantrolene (muscle relaxant) or bromocriptine (dopamine agonist)
Name three SGAs approved for the treatment of agitation.
Name two SGAs approved for the treatment of autism.
Name three SGAs approved for the treatment of depression.
Name six SGAs approved for the treatment of bipolard disorder and mania.
- asenapine (bipolar disorder only)
Which is the only SGA approved to treat psychosis?
SGAs have a similar mechanism of action compared to FGAs. The main difference is that SGAs have more affinity for the ____ receptor compared to the ____ receptor. This accounts for the reason SGAs are associated with less EPS.
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