Antipsychotics

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Author:
wetterlm
ID:
191512
Filename:
Antipsychotics
Updated:
2013-01-06 12:22:08
Tags:
antipsychotic
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Description:
Review of Psychotropic Agents
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  1. Low potency antipsychotropic agents tend to have less/more anticholinergic effects, hypotension and sedation in comparison to high potency agents.
    More anticholinergics effects, hypotension and sedation
  2. High potency first generation antipsychotics (FGAs) are associated with lower/higher rate of EPS when compared to low potency agents.
    Higher rates of EPS
  3. Dystonic reactions typically occur by the ___ day of antipsychotic treatment.
    4th
  4. Dystonic reactions include ____.
    Abruptly occurring spasms, most commonly those of the head and neck.
  5. Acute dystonic reactions can be treated with IV/IM (oral not recommended) ____ or ____.
    • Diphenhydramine 50mg, or
    • Benztropine 2mg
  6. Akathisia usually occurs within ____ weeks of new antipsychotic therapy.
    2-3
  7. Akathisia reactions include ____.
    • Inner restlessness
    • Pacing
    • Fidgeting
    • Desire to move for the sake of moving
  8. Akathisiamay respond to treatment with ____ or ____.
    • Beta-blockers, or
    • Benzodiazepines
    • (Or dose reduction, medication change)
  9. Parkinsonism is characterized by ____.
    • Rigidity
    • Hypokinesia
    • Akinesia (loss of arm swing when walking, loss of facial expression)
    • Tremor
  10. Parkinsonism usually occurs within ____ weeks after antipsychotic initiation.
    4
  11. Treatment of parkinsonism primarily involves ____ agents.
    Anticholinergic
  12. Tardive dyskinesia symptoms include ____.
    • Abnormal involuntary movements
    • Hypermobility of facial muscles and extremities
    • Lip smacking
    • Tongue thrusting
  13. The primary intervention for tardive dyskinesia is ____.
    Discontinue the offending agent
  14. Hallmarks of neuromuscular syndrome (NMS) are ____.
    • High fever
    • Muscle rigidity
    • Stuper
  15. Treatment for NMS includes ____.
    • Discontinuation of the drug
    • Supportive measures
    • Drug therapy, including dantrolene (muscle relaxant) or bromocriptine (dopamine agonist)
  16. Name three SGAs approved for the treatment of agitation.
    • aripiprazole
    • olanzapine
    • ziprasidone
  17. Name two SGAs approved for the treatment of autism.
    • aripiprazole
    • risperidone
  18. Name three SGAs approved for the treatment of depression.
    • aripiprazole
    • olanzapine
    • quetiapine
  19. Name six SGAs approved for the treatment of bipolard disorder and mania.
    • aripiprazole
    • olanzapine
    • quetiapine
    • ziprasidone
    • risperidone
    • asenapine (bipolar disorder only)
  20. Which is the only SGA approved to treat psychosis?
    ziprasidone
  21. SGAs have a similar mechanism of action compared to FGAs. The main difference is that SGAs have more affinity for the ____ receptor compared to the ____ receptor. This accounts for the reason SGAs are associated with less EPS.
    • 5HT2
    • D2

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