rosiglitazone(Avandia),pioglitazone(Actos)

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Author:
tville01
ID:
191897
Filename:
rosiglitazone(Avandia),pioglitazone(Actos)
Updated:
2013-01-10 20:12:09
Tags:
rosiglitazone Avandia pioglitazone Actos
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rosiglitazone(Avandia),pioglitazone(Actos)
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  1. What is the class of medication for rosiglitazone(Avandia)and pioglitazone(Actos)
    • Thiazolidinediones(glitazones)
    • insulin-sesitizing drugs
  2. What is the MOA of rosiglitazone(Avandia) and pioglitazone(Actos)
    regulates the genes involved in glucose and lipid metabolism by decreasing insulin resistance and enhancing sensitivity of insulin receptors
  3. What are the indications for rosiglitazone(Avandia) and pioglitazone(Actos)
    type 2 diabetes
  4. What are the contraindications of rosiglitazone(Avandia) and pioglitazone(Actos)
    pt with Class III or IV HF
  5. What are the adverse effects of rosiglitazone(Avandia) and pioglitazone(Actos)
    • ^ risk of HF
    • ^ risk of MI
    • weight gain
    • peripheral edema
    • decreased bone density, increased fractures
  6. The use of rosiglitazone(Avandia) and pioglitazone(Actos) is reserved for what pt
    Those who cannot control glucose with metformin or sulfonylureas due to coast, adverse effects, and slow onset
  7. What is the onset for rosiglitazone(Avandia) and pioglitazone(Actos)
    several weeks, takes months for max activity
  8. What is the route and dose of admin for rosiglitazone(Avandia) and pioglitazone(Actos)
    PO 15-45 mg daily
  9. Actos Interactions
    Increased actos serum concentrations when taken with ketoconazole or e-mycin

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