metaformin(Glucophage)

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Author:
tville01
ID:
191901
Filename:
metaformin(Glucophage)
Updated:
2013-01-10 20:09:57
Tags:
metaformin Glucophage
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Description:
metaformin(Glucophage)
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  1. Class of metaformin(Glucophage)
    Biguanide
  2. MOA of metaformin(Glucophage)
    • first-line drug
    • decrease glucose produced in liver,
    • decrease intestinal absorption of glucose
    • increase receptor sensitivity
  3. Indications of metaformin(Glucophage)
    • Newly diagnosed type 2 diabetes(1st line)
    • can cause weight loss for overweight diabetics
  4. What can metaformin(Glucophage) be used in conjunction with
    • sulfonylureas
    • thiazolidinediones
    • insulin
  5. Contraindications of metaformin(Glucophage)
    • renal disease/dysfunction(primarily excreted through kidneys)
    • alcoholism
    • metabolic acidosis
    • hepatic disease
    • HF
    • cardiopulmonary disease
  6. Adverse side effects of metaformin(Glucophage)
    • abd bloating
    • nausea
    • cramping
    • full feeling
    • diarrhea
    • metallic taste
    • low B12 levels
    • lactic acidosis
  7. Interactions with metaformin(Glucophage)
    iodine contrast medium(renal failure/lactic acidosis), stop 48 hrs before radiologic studies
  8. Route and dose for metaformin(Glucophage)
    • PO 1000mg or 850 mg bid
    • max: adult-2550 mg, peds- 2000mg
  9. metaformin(Glucophage) interactions
    • Cimetidine
    • Iodine containing contrast

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