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Author:
icbcc
ID:
192543
Filename:
step3
Updated:
2013-01-13 12:59:19
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MTB
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antibiotics
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  1. Staph.aureus: Bone, Heart, Skin, Joint
    Sensitive staph(MSSA);
    1.IV
    2.Oral
    • 1.Oxacillin/nafcillin, or cefazolin(1st gen.)
    • 2. Dicloxacillin or cephalexin(1st gen).
  2. Staph.aureus-resistant staph(MRSA)
    1.severe infection(6)
    2. Minor infection(3)
    • 1. Vancomycin, linezolid, daptomycin, ceftaroline, tigecycline, or telavancin
    • 2. TMP/SMX. clindamycin, doxycycline
  3. Linezolid causes
    thrombocytopenia
  4. Daptomycin causes
    myopathy and rising CPK
  5. Staph aureus. Penicillin allergy:
    rash
    safe to use cephalosporins
  6. Staph aureus. Penicillin allergy:
    Anaphylaxis(2)
    Macrolides(azithromycin, clarithromycin) or clindamycin
  7. Staph aureus. Penicillin allergy:
    Severe infection(4)
    • Vancomycin
    • Linezolid
    • daptomycin
    • telavancin
  8. Staph aureus. Penicillin allergy:
    Minor infection:(3)
    • Macrolides(azithromycin, clarithromycin),
    • clindamycin
    • TMP/SMX
  9. Telavancin is
    a vancomycin derivative with similar efficacy
  10. Streptococcus
    These meds will cover Str. as well as Staph.
    But they are specific for Str.:(3)
    • Penicillin
    • Ampicillin
    • Amoxicillin
  11. Gram- bacilli(rods):(6)
    • E.coli
    • Enterobacter
    • Citrobacter
    • Morganella
    • Pseudomonas
    • Serratia
  12. Gram- bacteria antibiotics
    Cephalosporins(2)
    • cefepime
    • ceftazidime
  13. Gram- bacteria antibiotics
    Penicillins(2)
    • Piperacillin
    • Ticarcillin
  14. Gram- bacteria antibiotics
    Monobactam(1)
    Aztreonam
  15. Gram- bacteria antibiotics
    Quinolones(4)
    • Ciprofloxacin
    • Levofloxacin
    • Moxifloxacin
    • Gemifloxacin
  16. Gram- bacteria antibiotics
    Aminoglycosides(3)
    • Gentamicin
    • Tobramicin
    • Amikacin
  17. Gram- bacteria antibiotics
    Carbapenems(4)
    • Imipenem
    • Meropenem
    • Etrapenem
    • Doripenem
  18. Etrapenem is
    only carbapenem that does not cover Pseudomonas
  19. Piperacillin and ticarcillin also
    cover Str. and anaerobes
  20. Levofloxacin, gemifloxacin and moxifloxacin are
    excellent pneumococcal drugs
  21. Aminoglycosides work
    synergistically with other agents to treat Staph and Str
  22. Carbapenems are
    excellent antianaerobic meds. They cover Str. and all sensitive Staph(MSSA)
  23. Tigecycline covers
    MRSA and is broadly active against gram negative bacilli
  24. Gemifloxacin is
    quinolone for pneumonia
  25. Anaerobes
    GI anaerobes(becteroides):
    Metronidazole
    is the best med for abd. anaerobes
  26. Anaerobes
    GI anaerobes(becteroides):
    Carbapenems, piperacillin and ticarcillin
    are equal in efficacy for abd. anaerobes compared to metronidazole
  27. Anaerobes
    GI anaerobes(becteroides):
    Cefoxitin and cefotetan
    the only cephalosporins that cover anaerobes
  28. Anaerobes
    Respiratory anaerobes(anaerobic Strep)
    clindamycin is the best drug for anaerobic Strep
  29. Meds with no anaerobic coverage(5)
    • Aminoglycosides
    • Aztreonam
    • Fluoroquinolones
    • Oxacillin/nafcillin
    • all cephalosporins(except cefoxitin and cefotetan)
  30. Vancomycin is associated with
    • red man syndrome. Slow the rate of infusion
    • red, flushed skin from histamine release. From rapid infusion of vancomycin.

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