Antimicrobials

Card Set Information

Author:
stec0059
ID:
19259
Filename:
Antimicrobials
Updated:
2010-05-13 23:46:58
Tags:
Antimicrobials
Folders:

Description:
Microbiology final review
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user stec0059 on FreezingBlue Flashcards. What would you like to do?


  1. Penicillin (beta lactams)
    • CELL WALL SYNTHESIS INHIBITORS
    • inhibit PBPs, which help cross link NAG and NAM molecules of the peptidoglycan cell wall
    • b lactam ring and R group=structural
  2. Vancomycin
    • CELL WALL SYNTHESIS INHIBITORS
    • alter the terminal D-Ala of the peptidoglycan chain, inhibiting transpeptidation and cell wall synthesis
  3. Bacitracin
    • CELL WALL SYNTHESIS INHIBITORS
    • bind and inhibit carriers for peptidoglycan subunits
  4. Polymyxins
    • CELL MEMBRANE INHIBITORS
    • disrupt the biliayer by cleaving the phospholipids
  5. Imidazole
    • CELL MEMBRANE INHIBITOR
    • prevent membrane sterol synthesis
  6. Nystatin
    • CELL MEMBRANE INHIBITOR
    • bind membrane sterols
  7. Quinolones (2 ex)
    • NUCLEIC ACID SYNTHESIS INHIBITORS
    • bind and inhibit DNA gyrase
    • ex) Nalidixic acid
    • ex) Ciprofoloxacin
  8. Rifampin
    • NUCLEIC ACID SYNTHESIS INHIBITORS
    • bind and inhibit DNA polymerase
    • (prevents transcription of mRNA)
  9. Macrolides (2 ex)
    • PROTEIN SYNTHESIS INHIBITORS
    • bind 50S rRNA and block peptide elongation
    • ex) erythromycin
    • ex) azithromycin
  10. Tetracyclines
    • PROTEIN SYNTHESIS INHIBITORS
    • bind 30S ribosome and distort the A site to prevent tRNA binding
  11. Aminoglycosides (2 ex)
    • PROTEIN SYNTHESIS INHIBITORS
    • block 30S-50S binding
    • ex) streptomycin
    • ex) kanamycin
  12. sulfonamides
    • METABOLIC ENZYME INHIBITORS
    • block purine and pyrimidine synthesis
    • block metabolism of folic acid
  13. Triclosan
    • METABOLIC ENZYME INHIBITORS
    • block enoyl reductase and therefore fatty acid synthesis

What would you like to do?

Home > Flashcards > Print Preview