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What is the amino acid switch in Sickle Cell?
Valine in for Glutamic Acid
What Hgb percentages make up Sickle Cell Disease?
60% S and 40% F
What Hgb percentages make up Sickle Cell Trait?
60% A and 40% S
Some Signs of Sickle Cell?
- Normocytic, normochromic hemolytic anemia
- Retic count 5-20%
- Increased LDH and Biliruben
- Decreased haptoglobin
Some RBC forms present in Sickle Cell?
- Sickle cells
- Oat Cells
- Pappenheimer bodies
- HJ bodies
What is the Amino Acid substitution for HGB C disease?
Lysine in for Glutamic Acid
What HGB percentages are seen in Hb C disease?
95% C, 7% F
What HGB percentages are seen in Hb C trait?
60% A, 40% C
What are some things you will see on a smear for Hb C disease?
- HbC Crystals "Bars of gold"
- Some RBCs may be Hyperchromic
What are the Amino Acid substitutions for Hgb SC disease?
Valine in for Glutamic Acid and Lysine in for Glutamic Acid
What are the HGB percentages in Hb SC disease?
50% S, 50% C
Things you will see on a smear for Hb SC disease?
- Target Cells
- Folded Cels
- Glove Shaped Hgb SC crystals or washington monument shaped crystals
- Few sickled cells