Q2 Metoclopramide (Reglan)

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Author:
tville01
ID:
192955
Filename:
Q2 Metoclopramide (Reglan)
Updated:
2013-01-17 10:10:18
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Q2 Metoclopramide Reglan
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Q2 Metoclopramide (Reglan)
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  1. Route for Metoclopramide (Reglan)
    • IV
    • IM
    • PO
    • 1-2mg/kg(30 min prechemo, repeat q2h*2dose, then q3h*3doses)    
    • 10-20mg *1, end of surgery
  2. MOA of metoclopramide(Reglan)
    Blocks dopamine in chemreceptor zone→CTZ desensitized to GI impulses,stimulates peristalsis,  enhances stomach emptying
  3. Class of metoclopramide(Reglan)
    • Antiemetic
    • Prokinetic
    • Dopamine antagonist
  4. Indications for metoclopramide(Reglan)
    • Tx delayed gastric emptying
    • GERD
    • N&V
  5. Contraindications of metclopramide(Reglan)
    • Seizure disorder
    • Pheochromytoma
    • Breast Ca
    • GI obstruction
    • Pt w/allergy to procaine/ procainamide
  6. Adverse effects of metoclopramide(Reglan)
    • Extrapyramidal adverse effects in youths   Cardio-hypotension, supraventricualar tachycardia,
    • CNS- sedation, fatigue, restless, HA, dystonia
    • GI- dry mouth, N&V, diarrhea
    • *tardive dyskinesia w/long term use
  7. Interactions of metoclopramine(Reglan)
    • Alcohol-additive CNS depression
    • Antocholinergics & analgesics- block motility effects

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