pathophys

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Author:
buckwild
ID:
193251
Filename:
pathophys
Updated:
2013-01-16 17:56:24
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pathophys
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pathophys
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  1. chronic myeloid leukemia (CML)
    • onset 40-50 years
    • poor prognosis
    • malignant granulocytes that carry Philly chromosome
  2. acute myeloid leukemia (AML)
    • median age 64y
    • bone pain, anemia, thrombocytopenia, ^ infx
  3. chronic lymphoid leukemia (CLL)
    • 95% B-cell precursor
    • average age 65-70years
  4. acute lymphoblastic leukemia/lymphoma (ALL)
    • primarily affects children
    • onset at 3-7 years
    • good prognosis
  5. 2 types of neoplasms?
    myeloid and lymphoid
  6. hairy cell leukemia
    • rare, chronic lymphoid leukemia
    • more common in men
  7. plasma cell myeloma (multiple myeloma)
    • slow insidious onset
    • malignant mature plasma cells
    • exclusively in adults
    • bone pain first sign
  8. hodgkins  lymphoma
    • arise in lymph nodes
    • spreads to other lymph nodes
    • more commo in men
    • *Reed-sternberg cells
  9. non-hodgkin's lymphoma
    • older adults
    • begins in lymph nodes
    • no Reed-sternberg cells
  10. retrovirus? (HIV)
  11. what type of cells does HIV target?
    • helper T-cells (CD4+ lymphocytes)
    • also macrophages (contains CD4 marker)
  12. HIV structure
    • RNA retrovirus.
    • core, proteins, enzymes protected by a lipid bilayer envelope
    • attaches to CD4+, injects RNA
    • reverse transcriptase transforms it into DNA
    • DNA migrates to nucleus, integrated into host
    • host begins making HIV RNA coding, produses more HIV
  13. progression of HIV
    • HIV infection leads to decline in CD4+ cells
    • initial infx flu-like symptoms
    • frequent opportunistic infections
    • latency period (years, decades)
    • considered AIDS when CD4+ count is <200
  14. most common cause of death from opportunistic infx in AIDS patients?
    tuberculosis

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