Card Set Information
Inflammation Immune Response
Medical Surgical Nursing
WBC- normal adult values
Iron level- normal adult values
55-70% of total WBC count. Increased in acute pus forming infection, decreased in overwhelming bacterial infection (older adult)
Growth of a stem cell into a mature neutrophil is
Life span is
Can only take part in one episode of phagocytosis.
20-40%. Increased in chronic bacterial and viral infection, decreased in sepsis
5-10% of total WBC count. Increased in protozoan, rickettsial, and tuberculosis infections. Fixed or non fixed. Limited activity until mature.
1-4% of total WBC count. Increased in parasitic infection.
Come from myeloid line.
# of eosinohils increased during allergic reactions.
0.5-1.5% of total WBC count. Normal during infection. Come from myeloid line. Functions by releasing chemicals including heparin, histamine, serotonin, etc.
Leukocytes involved in inflammation
Leukocytes involved in antibody-mediated immunity
Leukocytes involved in cell-mediated immunity
Helped/inducer T Cells
Cytotoxic/cytolytic T Cell
Natural Killer Cell
come from the committed myeloid stem cells in the bone marrow. The liver, sleep, and intestinal tract contain a large number of these cells.
Have long life spans and partake in many phagocytic events.
Seven steps involved in Phagocytosis
Exposure and Invasion
Age related immune changes- Inflammation
Neutrophil function defective
absence of leukocytosis
Age related immune changes- antibody mediated immunity
Diminished capability to produce new antibodies
decline in natural antibodies
decreased response to antigens
decreased antibody response time
Age related immune changes- cell mediated immunity
decreased thymus gland function
decreased number of T lymphocytes
Stage 1 of Inflammation response
Involves changes in blood vessels
Cause redness and warmth of tissues. The increased bloodflow delivers nutrients to injured tissues.
Macrophage is major cell in stage 1.
Stage 2 of inflammation response
Cellular exudate part of response.
Neutrophil is most active cell in this stage.
Arachidonic acid cascade starts.
Stage 3 of inflammation response
tissue repair and replacement.
Seven steps needed to produce a specific antibody directed against a specific antigen
antibody production and release
antibody binding reactions
sustained immunity or memory
ability to recognize own cell's vs. foreign cells
human leukocyte antigen
UPC code for individuals
present on nearly all body cells
determine tissue type
'systems' involved in the immune system
GI system, nervous system, endocrine system
5 cardinal signs of inflammation
warmth, redness, swelling, pain, loss of function.
CMI regulates the immune system by production and activity of cytokines. These are small protein hormones produced by many WBCs.