Quarter 2 Spinal neurology Sec 2 inflammation
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What are the five cardinal signs of inflammation?
- Loss of function
What cardinal sign is caused by fluid release, chemicals, biproducts, and microirritations
What are the three events of acute inflamation?
- 1. Vasodilation
- 2. Vascular leakage and edema
- 3. Leukocyte emigration (phagocytosis)
What occurs briefly before vasodilation?
What acute inflammation event causes warmth / redness, opens microvascular bed, and increases the intravascular pressure
Where does fluid build up during edema?
between cell and tissue
what type of vascular leakage does inflammation cause?
What would be seen in fluid the is released due to exudate release?
- High Density fluid
What do histamines, bradykinins, and leukotrienes cause and in what stage of inflammation?
- Immediate transient endothelial cell contraction
- During first 15 to 30 min of vascular leakage (in vanules only)
What is it called when when leukocytes move toward gap in endothelium?
margination and rolling
What mediates early rolling adhesion?
- E-Selectin (endothelium)
- P-Selectin (platelets)
- L-Selectin (leukocytes)
What are the first white blood cells to transmigrate (Diapedesis)
Polymorphic Neutrophils (PMN) (phagocytes)
What cells recognize what needs to be attacked?
What cells build the immunolgobin.
What are cytokines, LTB4, Soluble bacterial products, complement component C5
What chemotaxis are used to communicate between cells?
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