SGU Pharmacology basics

Card Set Information

Author:
SGU
ID:
193666
Filename:
SGU Pharmacology basics
Updated:
2013-01-20 17:00:56
Tags:
SGU Pharmacology basics
Folders:

Description:
Flash cards for pharmacology at St. George's University SOM.
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user SGU on FreezingBlue Flashcards. What would you like to do?


  1. Dosing Rate = 


    • TC = target concentration
    • F = bioavailability
  2. Loading Dose = 


    • TC = target concentration
    • F = bioavailability
  3. Vd =


    or

  4. CL =


    or

      (for first order)

    or

      (for zero order)
  5. t1/2 =
  6. Efficacy
    The maximal effect (Emax) an agonist can produce.
  7. Potency
    The concentration (EC50) of a drug required to produce 50% of the maximal effect.
  8. Chemical antagonism example:
    Protamine - positively charged and counteracts the negatively charged heparin.
  9. Inverse antagonist examples (2):
    Famotidine & Metoprolol
  10. Tachyphylaxis
    Desensitization, or the effect of a drug to gradually diminish when given continuously or repeatedly.
  11. Therapeutic index = 


    or

  12. Henderson-Hasselbalch equation:
    pH = pK + log
  13. F =


    F = bioavailability
  14. Bioequivalence = 
    If the two concentration-time plots are nearly superimposable, the preparations are said to be bioequivalent:  one can replace the other safely.
  15. In plasma:

    acidic drugs bind =

    basic drugs bind =
    acidic = albumin

    basic = alpha1-acid glycoprotein
  16. Warfarin-sulfonamide interaction:
    Sulfonamide displaces warfarin from albumin, causing a massive increase in plasma concentration, which may lead to bleeding.
  17. Enzyme systems involved in phase I conjugation reactions are located in:
    the ER
  18. Enzyme systems involved in phase II conjugation reactions are located in:
    the cytosol
  19. xenobiotic receptors (3):
    aryl hydrocarbon receptor (AhR)

    pregnane X receptor (PXR)

    constitutively active receptor (CAR)

    [all promote CYP induction]
  20. carbamazepine
    antiepileptic that induces CYP3A4 and is metabolized by CYP3A4.
  21. Drugs that increase the synthesis of one or more P450 isoforms (3):
    phenobarbital

    rifampin

    carbamazepine
  22. Drugs that significantly inhibit P450 isoforms:
    amiodarone, cimetidine, azole antifungals (ketoconazole), macrolide antibiotics (erythromycin), chloramphenicol, ritonavir, grapefruit juice (furanocoumarins)

    bold: appears on drug list
  23. Acetaminophen metabolism:
    5% metabolized by CYP2E1 to NAPQI, which is toxic to liver tissues
  24. Antidote to acetaminophen poisoning:
    N-acetylcysteine
  25. Glomerular capillary filtration size:
    MW < 20,000
  26. Zero-order elimination is reached with (3):
    aspirin

    ethanol

    phenytoin

    A constant amount of drug is eliminated per unit time.
  27. Accumulation Factor (AF) =
  28. PCss =
    PC1 x AF

What would you like to do?

Home > Flashcards > Print Preview