Card Set Information
T cell marker of polypeptides
glycoprotein marker of Th1 to recognize MHCII
glycoprotein marker of cytotoxic T cells to recognize MHCI
only on B cells
NK cell marker
leukocyte common antigen
monomer that is free in the plasma
in primary and secondary response
CAN cross placenta
pentamer, free on surface
Receptor on B cell
1st Ig released for B activation
on the surface of B
Mature B cell, important for B cell activation
dimer that can circulate (as monomer) or secreted as a dimer
plasma cell in GI and respiratory tract
on mast cells and basophils, can release histamine that contributes to allergic response
For parasitic infections
B cell zone in the spleen?
T cell zone in the spleen?
B cell zone in lymph nodes?
in the cortex
T cell zone in the lymph node?
Cells of myeloid origin?
monocyte (macrophage, dendritic cell), granulocyte (neutrophil, basophil, eosinophil)
has a tick over for innate response
C3-->cleaved to C3a and C3b via C3 convertase (made of C3bBb)-->properdin stabilizes -->Factor H & I are for enzymatic degradation or by DAF (decay accelerating factor)
What is the MAC? When is it activated?
triggered by C5 convertase
made of C5C6C7C8C9 to form a pore
can be blocked by pore formation by CD59
Needs Ag to bind to activate except via CRP
C1q binds to the Fc region of Ab-->C1q & C1s bind and cleave C4 & C2 -->form complex-->C5 convertase (C4b2b3b) -->MAC (C5C6C7C8C9)
initiated by binding to MBL (mannose residue) part of innate response
MBL-activated serine protease (MASP activation) -->cleave C4 & C2-->C3 convertase (C4b2a) -->cleaves C3--->C3b binds to surface
worst type of deficiency?
C3! since involved in all the pathways
Type 1 IFNs?
IFN-alpha and IFN-beta
produced by virus infected cells to act on surrounding infected cells
increase expression of MHC1 on virally infected cells
Increase expression of NK cells and activate NK cells
Type 2 IFN?
NK cells activate Th1 -->activate macrophages & antagonize Th2 responses
secreted by NK cells, enhance macrophages killing, increase MHC1
IL-1, IL-6, IL-8, IL-12, IFNs, TNF-alpha
Antigen presenting cells?
dendritic cells, macrophages, B cells
Cell-mediated cytokines in adaptive immunity?
IL-2, IL-12, IL-23, IFN-gamma, TNF
humeral cytokines in adaptive immunity?
IL-4, IL-5, IL-7, IL-9, IL-10, IL-13
Intracellularly located pathogens in the cytoplasm?
virus, listeria, protozoa
defended by NK cells
Extracellularly located pathens?
virus, bacteria, protozoa, fungi, parasites
Defend by complement, macrophages, neutrophils, antimicrobial peptides
Intracellularly located vesicular pathogens?
mycobacteria, trypanosomes, cryptococcus neoformans
Defend by macrophages
PRR binding binding ding to PAMP pathway
LPS --> TLR4 or CD14 > NFkB and MapK signal > NFkB minus lkB to nucleus > gene expression > TNFalpha
iL6, TNF alpha, IL 1beta
TNF alpha, IL1beta, CXCL8, IL12