Immuno

Card Set Information

Author:
jrf322
ID:
194432
Filename:
Immuno
Updated:
2013-01-22 11:47:07
Tags:
IMMUNO
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Description:
Block 1
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  1. CD3 function?
    T cell marker of polypeptides
  2. CD4?
    glycoprotein marker of Th1 to recognize MHCII
  3. CD8?
    glycoprotein marker of cytotoxic T cells to recognize MHCI
  4. CD19?
    only on B cells
  5. CD56?
    NK cell marker
  6. CD45?
    leukocyte common antigen
  7. IgG?
    • monomer that is free in the plasma¬†
    • in primary and secondary response
    • CAN cross placenta
  8. IgM?
    • pentamer, free on surface
    • Receptor on B cell
    • 1st Ig released for B activation
  9. IgD
    • monomer
    • on the surface of B
    • Mature B cell, important for B cell activation
  10. IgA
    • dimer that can circulate (as monomer) or secreted as a dimer
    • plasma cell in GI and respiratory tract
    • on mast cells and basophils, can release histamine that contributes to allergic response
    • For parasitic infections
  11. B cell zone in the spleen?
    lymphoid follicle
  12. T cell zone in the spleen?
    PALs
  13. B cell zone in lymph nodes?
    in the cortex 
  14. T cell zone in the lymph node?
    paracortex
  15. Cells of myeloid origin?
    monocyte (macrophage, dendritic cell), granulocyte (neutrophil, basophil, eosinophil)
  16. CD34?
    addressin molecule
  17. Alternative pathway?
    • has a tick over for innate response
    • C3-->cleaved to C3a and C3b via C3 convertase (made of C3bBb)-->properdin stabilizes -->Factor H & I are for enzymatic degradation or by DAF (decay accelerating factor)
  18. What is the MAC? When is it activated?
    • triggered by C5 convertase
    • made of C5C6C7C8C9 to form a pore
    • can be blocked by pore formation by CD59
  19. Classical pathway?
    • Needs Ag to bind to activate except via CRP
    • C1q binds to the Fc region of Ab-->C1q & C1s bind and cleave C4 & C2 -->form complex-->C5 convertase (C4b2b3b) -->MAC (C5C6C7C8C9)
  20. Lectin pathway?
    • initiated by binding to MBL (mannose residue) part of innate response
    • MBL-activated serine protease (MASP activation) -->cleave C4 & C2-->C3 convertase (C4b2a) -->cleaves C3--->C3b binds to surface
  21. worst type of deficiency?
    C3! since involved in all the pathways
  22. Type 1 IFNs?
    • IFN-alpha and IFN-beta
    • produced by virus infected cells to act on surrounding infected cells
    • increase expression of MHC1 on virally infected cells
    • Increase expression of NK cells and activate NK cells
  23. Type 2 IFN?
    • IFN-gamma
    • NK cells activate Th1 -->activate macrophages & antagonize Th2 responses
    • secreted by NK cells, enhance macrophages killing, increase MHC1
  24. Pro-inflammatory interleukins?
    IL-1, IL-6, IL-8, IL-12, IFNs, TNF-alpha
  25. Anti-inflammatory interleukins?
    IL-10, TGF-beta
  26. Antigen presenting cells?
    dendritic cells, macrophages, B cells
  27. Cell-mediated cytokines in adaptive immunity?
    IL-2, IL-12, IL-23, IFN-gamma, TNF
  28. humeral cytokines in adaptive immunity?
    IL-4, IL-5, IL-7, IL-9, IL-10, IL-13
  29. Intracellularly located pathogens in the cytoplasm?
    • virus, listeria, protozoa
    • defended by NK cells
  30. Extracellularly located pathens?
    • virus, bacteria, protozoa, fungi, parasites
    • Defend by ¬†complement, macrophages, neutrophils, antimicrobial peptides
  31. Intracellularly located vesicular pathogens?
    • mycobacteria, trypanosomes, cryptococcus neoformans
    • Defend by macrophages
  32. PRR binding binding ding to PAMP pathway
    LPS --> TLR4 or CD14 > NFkB and MapK signal > NFkB minus lkB to nucleus > gene expression > TNFalpha
  33. Systemic Interleukin?
    iL6, TNF alpha, IL 1beta
  34. Local interleukins
    TNF alpha, IL1beta, CXCL8, IL12

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