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T cell marker of polypeptides
glycoprotein marker of Th1 to recognize MHCII
glycoprotein marker of cytotoxic T cells to recognize MHCI
leukocyte common antigen
- monomer that is free in the plasma
- in primary and secondary response
- CAN cross placenta
- pentamer, free on surface
- Receptor on B cell
- 1st Ig released for B activation
- on the surface of B
- Mature B cell, important for B cell activation
- dimer that can circulate (as monomer) or secreted as a dimer
- plasma cell in GI and respiratory tract
- on mast cells and basophils, can release histamine that contributes to allergic response
- For parasitic infections
B cell zone in the spleen?
T cell zone in the spleen?
B cell zone in lymph nodes?
in the cortex
T cell zone in the lymph node?
Cells of myeloid origin?
monocyte (macrophage, dendritic cell), granulocyte (neutrophil, basophil, eosinophil)
- has a tick over for innate response
- C3-->cleaved to C3a and C3b via C3 convertase (made of C3bBb)-->properdin stabilizes -->Factor H & I are for enzymatic degradation or by DAF (decay accelerating factor)
What is the MAC? When is it activated?
- triggered by C5 convertase
- made of C5C6C7C8C9 to form a pore
- can be blocked by pore formation by CD59
- Needs Ag to bind to activate except via CRP
- C1q binds to the Fc region of Ab-->C1q & C1s bind and cleave C4 & C2 -->form complex-->C5 convertase (C4b2b3b) -->MAC (C5C6C7C8C9)
- initiated by binding to MBL (mannose residue) part of innate response
- MBL-activated serine protease (MASP activation) -->cleave C4 & C2-->C3 convertase (C4b2a) -->cleaves C3--->C3b binds to surface
worst type of deficiency?
C3! since involved in all the pathways
Type 1 IFNs?
- IFN-alpha and IFN-beta
- produced by virus infected cells to act on surrounding infected cells
- increase expression of MHC1 on virally infected cells
- Increase expression of NK cells and activate NK cells
Type 2 IFN?
- NK cells activate Th1 -->activate macrophages & antagonize Th2 responses
- secreted by NK cells, enhance macrophages killing, increase MHC1
IL-1, IL-6, IL-8, IL-12, IFNs, TNF-alpha
Antigen presenting cells?
dendritic cells, macrophages, B cells
Cell-mediated cytokines in adaptive immunity?
IL-2, IL-12, IL-23, IFN-gamma, TNF
humeral cytokines in adaptive immunity?
IL-4, IL-5, IL-7, IL-9, IL-10, IL-13
Intracellularly located pathogens in the cytoplasm?
- virus, listeria, protozoa
- defended by NK cells
Extracellularly located pathens?
- virus, bacteria, protozoa, fungi, parasites
- Defend by complement, macrophages, neutrophils, antimicrobial peptides
Intracellularly located vesicular pathogens?
- mycobacteria, trypanosomes, cryptococcus neoformans
- Defend by macrophages
PRR binding binding ding to PAMP pathway
LPS --> TLR4 or CD14 > NFkB and MapK signal > NFkB minus lkB to nucleus > gene expression > TNFalpha
iL6, TNF alpha, IL 1beta
TNF alpha, IL1beta, CXCL8, IL12