Neoplasia 1

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  1. What is neoplasia?
    uncontrolled growth of cells whose proliferation cannot be adequately controlled by normal regulatory mechanisms in normal tissues
  2. Why is cancer called "cancer"?
    • latin word for crab
    • tumors invade tissues like crawling crabs
  3. What does the word tumor mean?
  4. What are some other names for tumor?
    • mass
    • lump
    • growth
  5. What is oncology?
    the study of neoplasia
  6. What is the proliferation of normal cells regulated by?
    • genetic program of each cell
    • signals transmitted between cells by direct contact
    • various soluble substances which have growth promoting or inhibiting effects
  7. What happens once cells stop proliferating?
    they assume specialized functions by activating specific genes and suppressing unneeded genes
  8. Do cancer cells usually achieve the same level of differentiation as normal cells?
  9. Describe the growth of a tumor cell.
    • autonomous
    • excessive
    • disorganized
  10. How is the growth of a tumor cell autonomous?
    independent of growth factors and stimuli that promote the growth of normal cells
  11. How is the growth of a tumor cell excessive?
    do not respond to normal regulations of cell proliferation - growth does not stop
  12. How is the growth of a tumor cell disorganized?
    random growth - does not try to form normal tissue
  13. Can more than one type of neoplasia occur in an individual?
  14. Are all cells in a tumor neoplastic?
    • no
    • supportive elements are not neoplastic - connective tissue, blood vessels
  15. What can interfere with the recognition of a tumor?
    • hemorrhage
    • necrosis
    • inflammation
  16. Can spontaneous regression of neoplasia occur?
  17. Can tumors develop from any cell type?
  18. What are the different types of neoplasia of the spleen?
    • lymphosarcoma (lymphocytes)
    • hemangiosarcoma (blood vessels)
  19. What are the different types of neoplasia of the skin?
    • melanomas (melanocytes)
    • sebaceous adenomas (oil glands)
    • lipomas (adipose cells)
  20. Not all masses are neoplasms.  What types of masses are not neoplastic?
    • granulomas
    • cysts
    • abscesses
    • hyperplastic nodules (spleen, prostate, mammary)
  21. Not all neoplasms are masses.  What are some  neoplasms that are not masses?
    • leukemia (malignant cells in circulation)
    • diffuse infiltration or enlargement of an organ
  22. Does the size of the tumor indicate the degree of malignancy?
    • no
    • tiny tumors can be malignant, large tumors can be benign
  23. Can neoplasia be present as a non-healing lesion or as an ulcerated mass?
  24. Is neoplasia usually a different color from adjacent normal tissue?
  25. Can we identify neoplasia by a gross exam?
    • no
    • microscopic identification is needed
  26. Why is important to identify the specific type of neoplasia?
    for prognosis, treatment, and to predict the behavior of the tumor
  27. What is the role of the LVT regarding neoplasia?
    • recognize potential neoplasms (grossly and microscopically)
    • may observe tumor cells in sediment cytology of urine, body cavity fluid, blood smears, aspirates
    • prepare tissue for cytology
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Neoplasia 1
2013-01-23 23:01:02
Animal Diseases Two

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