AP II blood comp part 3

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  1. Should fresh frozen plasma be used as primary therapy for a specific coagulation defecit?
    NO!!!! (not id specific coagulation factors are available)
  2. What  blood product contains all of the soluble plasma proteins from one unit of whole blood?
  3. What is Cryoprecipitate?
    fraction of plasma the precipitates when FFP is thawed. 
  4. CRYO contains factor ___, and ____ mg of F_______.
    VIII, fibrinogen
  5. Name 3 indications for FFP admin
    • 1- correct bleeding- warfarin
    • 2- vit K deficit
    • 3- deficiency of multiple coag factors

    BONUS: Tx of TTP-HUS
  6. Cryo is indicated in the presence Hyper_______, due to massive hemorrhage or ____.
    hyperfibrinogenemia, DIC
  7. define DIC
    disseminated Intravascular coagulopathy
  8. Cryo is given prophylactically for what pts? (2- c.f.d, a.f.v.d)
    • congenital fibrinogen deficiency
    • aquired factor VIII def
  9. Name 3 subtypes of transfusion reactions:
    • febrile
    • allergic
    • hemolytic
  10. what are the 5 possible complications of transfusion reactions?
    • transfusion reaction
    • disease transmission
    • suppression of cell-mediated immunitity
    • metabolic derangments
    • transfusion-related acute lung injury
  11. How often do febrile rx occur in transfusion?
  12. febrile rxn is caused by reaction between donor ______ on the luekocytes/platelets with recipient ________
    antigens, antibodies
  13. is a febrile transfusion rxn usually benign?
  14. What are signs of febrile transfusion rxn?
    fever, chills, dyspnea
  15. Can a mild Allergic rxn to blood occur in properly type and cross matched?
  16. what are signs of a mild allergic rxn to blood transfusion? (2)
    • ^ Temp
    • pruritis
  17. Tx of mild allergic rxn to blood transfusion consists of IV ________ and stopping transfusion if severe.
  18. Hemolytic blood transfusion rxn is considered an _____________.
  19. Hemolytic blood transfusion rxn is a result of what?  What causes it?
    ABO incompatible blood
  20. Hemolytic blood transfusion rxn causes destruction of _______ ____________ by recipient antibodies.
    donor erythrocytes
  21. what is most common cause of Hemolytic blood transfusion rxn?
    clerical or procedural error
  22. What are the clinical manifestations of Hemolytic blood transfusion rxn?
    • Hypotension
    • Fever
    • Chills
    • dyspnea
    • skin flushing
    • pain in lumbar/sternum
  23. TX of Hemolytic blood transfusion rxn- 2 steps
    • 1- STOP transfusion
    • 2- maintain airway, HR, urine output
  24. should you discard the bag of PRBC's if a hemolytic transfusion reaction occurs?
  25. When treating hypotension of Hemolytic blood transfusion rxn, what 2 fluids should NOT be used?
    LR, dextrose
  26. What is most severe form of transfusion reaction?
  27. what are the signs of anaphylactic transfusion rxn? (5)
    • rapid onset
    • shock
    • hypotension
    • angioedema
    • respiratory distress
  28. anaphylactic transfusion rxn is usually due to the presence of class-specific ___
  29. anaphylactic transfusion rxn usually not seen when admin what blood products?
    • normal serum albumin
    • caog factors
  30. What are the 5 steps of treating anaphylactic transfusion rxn?  SEAVV
    • Stop trans
    • Epi
    • Airway maintenance
    • Volume "
    • Vasopressors as needed
  31. Disease transmission from blood products occurs in <1% for what virus?
  32. Rank the probability of getting the following viruses from greatest to least: Hep B, Hep C, HIV
    Hep B>Hep C>HIV
  33. What is TRALI?
    transfusion related acute lung injury
  34. what are the2 key determing factors that seperate TRALI from other transfusion problems?
    Pulmonary edema, L vent failure
  35. How soon will TRALI signs begin?
    2-4hrs after infusion
  36. TRALI recovery time is ____ hrs and treatment is merely ____________.
    96, supportive
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AP II blood comp part 3

monroe lecture part 3
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