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Should fresh frozen plasma be used as primary therapy for a specific coagulation defecit?
NO!!!! (not id specific coagulation factors are available)
What blood product contains all of the soluble plasma proteins from one unit of whole blood?
What is Cryoprecipitate?
fraction of plasma the precipitates when FFP is thawed.
CRYO contains factor ___, and ____ mg of F_______.
Name 3 indications for FFP admin
- 1- correct bleeding- warfarin
- 2- vit K deficit
- 3- deficiency of multiple coag factors
BONUS: Tx of TTP-HUS
Cryo is indicated in the presence Hyper_______, due to massive hemorrhage or ____.
disseminated Intravascular coagulopathy
Cryo is given prophylactically for what pts? (2- c.f.d, a.f.v.d)
- congenital fibrinogen deficiency
- aquired factor VIII def
Name 3 subtypes of transfusion reactions:
what are the 5 possible complications of transfusion reactions?
- transfusion reaction
- disease transmission
- suppression of cell-mediated immunitity
- metabolic derangments
- transfusion-related acute lung injury
How often do febrile rx occur in transfusion?
febrile rxn is caused by reaction between donor ______ on the luekocytes/platelets with recipient ________
is a febrile transfusion rxn usually benign?
What are signs of febrile transfusion rxn?
fever, chills, dyspnea
Can a mild Allergic rxn to blood occur in properly type and cross matched?
what are signs of a mild allergic rxn to blood transfusion? (2)
Tx of mild allergic rxn to blood transfusion consists of IV ________ and stopping transfusion if severe.
Hemolytic blood transfusion rxn is considered an _____________.
Hemolytic blood transfusion rxn is a result of what? What causes it?
ABO incompatible blood
Hemolytic blood transfusion rxn causes destruction of _______ ____________ by recipient antibodies.
what is most common cause of Hemolytic blood transfusion rxn?
clerical or procedural error
What are the clinical manifestations of Hemolytic blood transfusion rxn?
- skin flushing
- pain in lumbar/sternum
TX of Hemolytic blood transfusion rxn- 2 steps
- 1- STOP transfusion
- 2- maintain airway, HR, urine output
should you discard the bag of PRBC's if a hemolytic transfusion reaction occurs?
When treating hypotension of Hemolytic blood transfusion rxn, what 2 fluids should NOT be used?
What is most severe form of transfusion reaction?
what are the signs of anaphylactic transfusion rxn? (5)
- rapid onset
- respiratory distress
anaphylactic transfusion rxn is usually due to the presence of class-specific ___
anaphylactic transfusion rxn usually not seen when admin what blood products?
- normal serum albumin
- caog factors
What are the 5 steps of treating anaphylactic transfusion rxn? SEAVV
- Stop trans
- Airway maintenance
- Volume "
- Vasopressors as needed
Disease transmission from blood products occurs in <1% for what virus?
Rank the probability of getting the following viruses from greatest to least: Hep B, Hep C, HIV
Hep B>Hep C>HIV
What is TRALI?
transfusion related acute lung injury
what are the2 key determing factors that seperate TRALI from other transfusion problems?
Pulmonary edema, L vent failure
How soon will TRALI signs begin?
2-4hrs after infusion
TRALI recovery time is ____ hrs and treatment is merely ____________.