NSAIDs

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Author:
xinchen3
ID:
195091
Filename:
NSAIDs
Updated:
2013-01-27 12:41:45
Tags:
NSAID
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Description:
NSAID
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  1. Aspirin (ASA)
    COX inhibitor
  2. Methyl-salicylate
    COX inhibitor
  3. Ibuprofen
    COX inhibitor
  4. Naproxen
    COX inhibitor
  5. Keoprofen
    COX inhibitor
  6. Indomethacin
    COX inhibitor
  7. Phenylbutazone
    COX inhibitor
  8. Piroxicam
    COX inhibitor
  9. Sulindac
    COX inhibitor
  10. Use of COX inhibitors
    • anti-pyretic
    • anti-inflammatory
    • analgesic
    • inhibit platelet aggregation
  11. Adverse effect of NSAID
    • Renal & Liver toxicity
    • GI irritation & ulcer
    • Renal ischemia
    • Bleeding
    • Delay labor
  12. Contraindications of NSAID
    • anti-hypertensives
    • anti-coagulants
    • Alcohol
    • Digoxin
    • Hypoglycemics
    • GI ulcers
    • Pregnancy
    • Children (Reye's syndrome)
  13. what is unique about Ketoprofen
    • also inhibits lipooxygenase
    • great for inflammatory asthmatic attacks
  14. Celecoxib
    COX2 inhibitor
  15. Lumiracoxib
    COX2 inhibitor
  16. Rofecoxib
    COX2 inhibitor
  17. Valdecoxib
    COX2 inhibitor
  18. Acetaminophen
    COX3 inhibitor (in CNS)
  19. what makes COX2 inhibitor different from COX inhibitor
    • more selective for COX2 thus less side effects
    • #1: less GI disturbances!!!
    • #2: DO NOT affect platelets!!!
  20. important adverse effect of Rofecoxib & Valdecoxib
    • off market due to Cardiac Arrhythmia
  21. what makes Acetaminophen different from NSAIDs
    • no anti-inflammatory effects!
    • used only for the pain

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