antiplatelet drugs.txt

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Author:
kavinashah
ID:
19519
Filename:
antiplatelet drugs.txt
Updated:
2010-05-16 19:10:13
Tags:
antiplt
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Description:
antiplt
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  1. what is the MOA of aspirin?
    stops conversion of AA into TXA2: to stop platelet aggregation
  2. what is the MOA of clopidogrel?
    inhibits ADP receptor: needed for platelet aggregation
  3. what is the MOA of dipyradimole?
    PDE inhibitor: therefore increasing cAMP in the cell which blocks the platelet response to ADP
  4. what are the SE of aspirin?
    • GI bleed
    • perforate ulcer
    • hyperuricaemia
    • asthma
  5. what is the antiplatelet regimen for stroke?
    • aspirin 300mg initially
    • 75mg daily lifelong
  6. what is the antiplatelet regimen for TIA?
    • aspirin 300mg initially
    • 75mg daily lifelong
  7. what is the antiplatelet regimen for unstable angina?
    • aspirin 300mg initially
    • 75mg daily lifelong
    • +/- clopidogrel 300mg initially and 75mg daily lifelong
    • iv GPIIb/IIIa blocker for high risk angioplasty or stent insertion
  8. what is the antiplatelet regimen for post stent insertion?
    • aspirin 75mg daily lifelong
    • clopidogrel 75mg daily for 4 weeks
  9. what is the antiplatelet regimen for AMI?
    • aspirin 300mg initially
    • 75mg daily lifelong

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