Lutheran BG System
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What chormosome is the LU locus on and what is it linked to?
- Chromosome 19
- Linked to the SE locus.
What product is produced from the SE locus?
At position 77, what does Lua show?
At position 77, what does Lub show?
3here are 3 modes of inheritance for the LU system. Name 1 and a description.
InLu dominant supperssor gene at another locus suppress expression of the Lu antigen. Does not make Anti-Lu3. Other Lu antignes will be extremely weak
What is another mode of inheritiance for the LU system?
X-Linked dominant - which also suppreses the gene. Extremely weak Lu antignes and does not make Anti-Lu3.
similar to the dominant InLu.
What is the final 3rd mode of inheritance for the LU system?
Recessive - The inheritance of 2 recessive null genes at the LU locus. This DOES produce Anti-Lu3 and NO antigens are pressent.
Of Lua and Lub which is high incidence and which is low.
- Lua is low incidence
- Lub is high incidence - Which means the majority of individual will express this antigen on their RBC's.
Lua is what type of antibody?
Typically it is a naturally occurring antibody.
Lub is what type of antibody?
Usually is an Alloantibody and is clinically significant!
What is the significance of Anti-Lub?
This has caused Transfusion reactions and Mild HDN.
If blood is needed, you would need to contact the reference lab.
You must provide antigen negative blood!
For Lub give:
- Lub :clinically significant
- Can react at all temp ranges.
- Phase: RT & AHG
- Enzymes: no change either way
For Lua list:
- Not clinically significant
- IgM can be IgG
- RT & AHG
- No change with Enzymes
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