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what is the inheritance of haemophilia A? which factor deficiency? which pathway?
X linked recessive - so more men
what is haemophilia B otherwise known as?
factor 9 deficiency
how do you treat haemophilia a?
replace F8 with recombinant F8
what are the symptoms of haemophilia?
bleed into joints
bleed into muscles
: haematoma which lead to NERVE palsy and COMPARTMENT syndrome due to PRESSURE
how should vaccines be given to haemophiliacs?
never im as bleed!
what 2 tests are done for diagnosis of haemophilia? and results?
if someone has a warfarin allergy, what can they use instead?
phenindione: MOA vit K antagonist
which rash is assoc. with antiphospholipid syndrome?
livedo reticularis on legs
what is the treatment for A severe pulmonary embolism affecting a central pulmonary artery ?
thrombolysis or even embolectomy
emergency!! don't delay for imaging
what type of anaemia would you expect an epileptic on phenytoin to have? and why?
phenytoid impairs folate metabolism
: get functional folate deficiency
from a FBC, how would you differentiate an iron deficiency anaemia from thalassaemia?
in thalassaemia: inc red cell count
what is HbA2?
made of 2alpha and 2delta globins due to lack of beta globins in b-thalassaemia
which disorders can cause hypersegmented neutrophils?
when do target cells come apparent?