Side Effects of Medications

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Author:
DruschKa
ID:
197439
Filename:
Side Effects of Medications
Updated:
2013-02-02 16:47:46
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Side effects drugs pharmacology
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Description:
What are the side effects of some medications?
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  1. Tacrolimus
    • HTN
    • High K
    • Low Phos
    • Low Mag
    • Nephrotoxicity
    • DM
    • Tremor 
    • Diarrhea
  2. Cyclosporin
    • HTN
    • Hyperlipidemia
    • Hirsutism, gingival hyperplasia
    • Nephrotoxicity
    • DM
    • Tremor
    • GI
  3. CellCept and Myfortic
    • (GI)
    • Diarrhea
    • Constipation
    • Nausea 
    • Vomiting

    • (Bone Marrow Suppression)
    • leukopenia (low WBC)
    • thrombocytopenia (low platelets)
    • anemia (low RBC)
  4. Sirolimus
    • Impaired wound healing
    • Delay in renal allograft recovery
  5. Sirolimus and Everolimus
    • HTN
    • high cholesterol
    • high triglycerides
    • hyperlipidemia
    • thrombocytopenia (low platelets)
    • anemia
    • diarrhea
    • Acne
    • Rash
  6. Corticosteroids
    • Glucose intolerance
    • Weight gain
    • Bone growth inhibition in children
    • Osteoporosis
    • HTN
    • Hyperlipidemia
    • Fluid retention
    • Low K
    • h/a
    • Thinning of skin/easy bruising
    • Psychic disturbances
  7. First 2 days of OKT2 (monoclonal antibodies) treatment
    • Cytokine release syndrome:
    • fever
    • chills
    • dyspnea
    • n/v
    • diarrhea
    • h/a
    • wheezing
    • tachycardia
    • rigors
    • HTN
  8. Campath (alemtuzumab) (monoclonal antibodies)
    • Infusion related side effects:
    • fever
    • chills
    • HTN/hypotension

    increased risk of opportunistic infection and autoimmune disorders
  9. Daclizumab and basiliximab (monoclonal Antibodies)
    Well tolerated. 

    Occ. infusion related a/e of fever and chills
  10. Atgam (anti thymocyte antibody, horse) (polyclonal antibodies)
    • Infusion related:
    • fever
    • chills
    • headache
    • leukopenia (low WBC)
    • thrombocytopenia (low platelets)
    • rash
    • n/v
    • diarrhea
    • increased risk of infection
  11. Thymoglobulin (anti thymocyte globulin, rabbit)
    • Infusion related:
    • fever
    • chills
    • headache
    • leukopenia (low WBC)
    • thrombocytopenia (low platelets)
    • HTN
    • tachycardia
    • dyspnea
    • ABD pain
    • diarrhea
  12. What is Serum Sickness (associated with Atgam- anti thymocyte antibody, horse)
    • Hypersensitivity response to blood serum containing polyclonal antibodies (used to pass on passive immunity). The human body mistakes these polyclonal antibodies for antigens and it reacts. 
    • Rashes
    • Fever
    • Itching
    • Joint Pain (arthralgia)
    • Hypotension
    • Malaise/Shock
    • Enlarged Spleen
    • Proteinuria
  13. NSAIDS (give examples and a/e)
    Ibuprofen, ASA, Tylenol, Naproxen

    Renal toxicity and dysfunction
  14. Which over the counter pain med is the safest?
    Tylenol
  15. Trimethoprim (TMP)/Sulfamethoxazole (SMX)
    • Hyperkalemia
    • h/a
    • GI disturbances
    • Neutropenia (low neutrophils)
    • Leukopenia (low WBC)
    • Thrombocytopenia (low platelets)
  16. Vancomycin- Infusion related histamine mediated
    • Nausea
    • Chills
    • Fever
    • Wheezing
    • Dsypnea
    • Urticaria
    • Rash
    • Nephrotoxicity
    • Neutropenia (low neutrophils)
    • Thrombocytopenia (low platelets)
  17. Ganciclovir
    • Nephrotoxicity
    • Increase liver enzymes
    • Neurotoxicity
    • GI symptoms
    • Fever/Chills
  18. Lamivudine (for Hep B tx)
    • Malaise
    • Fatigue
    • Resp. Tract Infection
    • h/a
    • ABD discomfort
    • Pain
    • n/v/d
  19. Fluconazole
    • Hepatotoxicity
    • GI disturbances
    • rash
    • h/a
  20. Amphotericin B (tx fungal infxn)
    • Nephrotoxicity
    • Hepatotoxicity
    • Hypokalemia
    • Hypomagnesemia
    • Anemia
    • n/v/d
  21. Ace inhibitors (Enalapril, Lisinopril, Quinapril, Rampril)
    • drug induced cough d/t kinin accumulation
    • Impaired renal function
    • hyperkalemia
  22. ARBs (Atacand, Losartan, Valsartan)
    similar to Ace inhibitors but no drug induced cough
  23. Statins (Atorvastatin, Pravastatin, Rosuvastatin, Simvastatin)
    • GI problems
    • n/v/d
    • Headache
    • dizziness
    • arthralgias
    • Myalgias
    • Increased creatinine kinase (found in muscles a.k.a. CK)
    • Increase Liver enzymes

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