Some Mechanisms of Drug Action

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  1. Drug increases the synthesis of NT molecules by serving as precursor
    • L-DOPA
    • (DA receptor diagram; can increase supply)
  2. Drug blocks the synthesis of NT molecules by destroying synthesizing enzymes
    • Carbidopa
    • (DA receptor diagram; can block this reaction)
  3. Drug causes the NT molecules to leak from the synaptic vesicles to cytoplasm where degrading enzymes destroy NT molecules
    • Resperine
    • (DA receptor diagram; can cause leakage from vesicles)
  4. Drug increases the number of NT molecules by destroying degrading enzymes
    • Deprenyl
    • (DA receptor diagram; can block this reaction)
  5. Drug increases the release of NT molecules from terminal buttons
    • Amphetamine
    • (DA receptor diagram; increases release)
  6. Drug blocks the release of the NT molecules from terminal buttons
    • Botulinum toxin
    • (Botox; not on diagram)
  7. Drug binds to postsynaptic receptors and activates them
    • Pergolide
    • (DA receptor diagram)
  8. Drug activates autoreceptors and inhibits NT release
    Apomorphine?
  9. Drug binds to the postsynaptic receptors and occupy them without activating them (blocking the receptor)
    • Haloperidol
    • (DA receptor diagram; "typical antipsychotic drug, blocks receptor)
  10. Drug blocks the deactivation of NT molecules by destroying degrading enzymes
    Sarin/aricept?
  11. Drug blocks the presynaptic transporter blocking reuptake
    • Cocaine
    • (DA receptor diagram; blocks reuptake)

Card Set Information

Author:
Anonymous
ID:
197919
Filename:
Some Mechanisms of Drug Action
Updated:
2013-02-04 22:52:53
Tags:
drug action psychopharmacology
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Description:
Set of cards created after another in-class diagram
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