Bmsc 230 Gluconeogenesis

The flashcards below were created by user Scottygo on FreezingBlue Flashcards.

  1. Gluconeogenesis
    • -Synthesis of Glucose from non-hexose precursors
    • -Occurs in all animals plants fungi and micro-organisms
  2. Where does gluconeogenesis occur
    • 95% in liver
    • some in kidney
    • (Glucose-6-phosphatase only exists in liver and kidney)
  3. What precursors do animals use for gluconeogenesis?
    Lactate, pyruvate, glycerol, and amino acids
  4. What precursors do plants use for glyconeogenesis?
    stored fats, proteins Image Upload 1 sucrose
  5. What precursors do micro-organisms use for glyconeogenesis?
    simple organic compounds: acetate, lactate, propionate Image Upload 2 Glucose
  6. What are the 3 bypass reactions in gluconeogenesis that differ from glycolosis?
    • 1) Pyruvate Image Upload 3 oxaloacetate
    • oxaloacetate Image Upload 4 phosphoenolpyruvate

    2) fructose 1,6-phosphate Image Upload 5 fructose 6-phosphate

    3) Glucose 6-PhosphateImage Upload 6Glucose
  7. Pyruvate to oxaloacetate
    • Pyruvate+CO2+ATPImage Upload 7ADP+Pi+Oxaloacetate
    • Enz: Pyruvate Carboxylase with Bioitin Prosthesis
    • Irreversable
    • Image Upload 8
  8. Biotin (B7)
    a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.
  9. Oxaloacetate to phosphoenolpyruvate
    • Oxaloaceetate+GTPImage Upload 9CO2+GDP+phosphoenolpyruvate
    • Enz: PEP carboxykinase
    • **Oxaloacetate is essentially just phosphoralized
    • Image Upload 10
  10. If Oxaloaceetate Image Upload 11 phosphoenolpyruvate reaction occurs outside of mitochondria what what must occur?
    • Oxaloacetate+NADHImage Upload 12NAD++Malate
    • (to transport out of mitochondria)
    • Enz: Mitochondrial Malate Dehydrogenase

    • Malate+NAD+Image Upload 13NADH+Oxaloacetate
    • (to proceed with reaction)
    • Enz: cytosolic Malate Dehydrogenase

    **Oxaloacetate can not be transported out of mitochondria
  11. Fructose 1,6-phosphateImage Upload 14 Fructose 6-phosphate
    • Fructose 1,6-phosphate+H2OImage Upload 15
    • Pi+Fructose 6-phosphate
    • Enz: Fructose 1,6-biphosphatase(FBPase-1)
    • irreversable
  12. Glucose-6-phosphateImage Upload 16Glucose
    • Glucose-6-phosphate+H2Image Upload 17 Glucose+Pi
    • Enz: Glucose 6-phosphatase
    • irreversable
  13. At what reactions are the 11 ATP equivalences required?
    • 1)2 ATP Pyruvate-oxaloacetate
    • 2)2 GTP Oxaloacetate-PEP
    • 3)2 ATP 3-phosphoglycerate-1,3bisphosphoglycerate
    • 4) 2 NADH 1,3phosphoglycerate-Glyceraldehyde 3-P
Author:
Scottygo
ID:
198032
Card Set:
Bmsc 230 Gluconeogenesis
Updated:
2013-02-07 01:37:08
Tags:
Bmsc 230 Gluconeogenesis
Folders:

Description:
Bmsc 230 Gluconeogenesis
Show Answers: