Bmsc 230 PPP

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functions of PPP Pathway

1) provide NADPH required for lipid synthesis through oxidative part of reaction

2)Provide R5P (ribose 5-phosphate) required for nucleotide synthesis
Where does PPP take place (4)
- everywhere that requires lipid synth
- -adipose tissue
- -Mammary Glands
- -Liver
- -Adrenal Cortex (Glands)
oxidative reaction
- - irreversable
- -produces 2 NADPH and CO₂per G6P
- -4 reactions from G6P to R5P
- -inhibited by high levels of NADPH
- -use of only oxidative part is production of NADPH and R5P
Intermediates of oxidative pathway
- 6-Phosphogluconolactone
- 6-Phosphogluconate
G6P6-Phosphogluconolactone
- Enz: Glucose 6-P dehydrogenase (inhibited by NADPH)
- reactants: NADP⁺
- products:NADPH+H⁺
- Irreversable
  **oxidation
6-Phosphogluconolactone6-Phosphogluconate
- Enz: Lactonase
- Reactants:H₂O
- Products:H⁺
- Irreversable
- **Opening of sugar ring
6-PhosphogluconateRibulose 5-P
- Enz: 6-Phosphogluconate dehydrogenase
- Reactants: NADP⁺
- Products:NADPH+H⁺+CO₂
- Irreversable
- **Oxidation and Decarboxilation
3 uses for Nonreducing part of PPP
- -production of R5P and not NADPH through reverse pathway
- -Cyclicle production of NADPH
- -Production of NADPH and ATP (Glycolosis through PPP)
7 Sugars of the Non-reducing part of the PPP pathway
- Ribulose 5-P
- Ribose 5-P
- xylulose 5-P
- sedoheptulose 7-P
- Erythrose 4-P
- Glyceraldehyde 3-P
- Fructose 6-P
Ribulose 5-P Ribose5-P
- Enz: Phosphopentose Isomerase
- Reversable
- **Aldehyde to Ketose
Ribulose 5-P Xylulose 5-P
- Enz: phosphopentose epimerase
- Reversable
Xylulose 5-P + Ribose 5-P Glyceraldehyde 3-P + Sedoheptulose 7-P
- Enz: Transketolase (TPP)
- Reversable
Xylulose 5-P + Ethrose 4-P Glyceraldehyde 3-P + Fructose 6-P
- Enz: Transketolase (TPP)
- Reversable
Glyceraldehyde + Sedoheptulose Ethrose 4-P + Fructose 6-P
- Enz: Transaldolase
- Reversable

Author

Scottygo

198278

Card Set

Bmsc 230 PPP

Description

Bmsc 230 PPP

Updated

2013-02-06T05:23:47Z

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