Bmsc 230 PPP

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Author:
Scottygo
ID:
198278
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Bmsc 230 PPP
Updated:
2013-02-06 00:23:47
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Bmsc 230 PPP
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Bmsc 230 PPP
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  1. functions of PPP Pathway
    1) provide NADPH required for lipid synthesis through oxidative part of reaction

    2)Provide R5P (ribose 5-phosphate) required for nucleotide synthesis
  2. Where does PPP take place (4)
    • everywhere that requires lipid synth
    • -adipose tissue
    • -Mammary Glands
    • -Liver
    • -Adrenal Cortex (Glands)
  3. oxidative reaction
    • - irreversable
    • -produces 2 NADPH and COper G6P
    • -4 reactions from G6P to R5P
    • -inhibited by high levels of NADPH
    • -use of only oxidative part is production of NADPH and R5P
  4. Intermediates of oxidative pathway
    • 6-Phosphogluconolactone
    • 6-Phosphogluconate
  5. G6P6-Phosphogluconolactone
    • Enz: Glucose 6-P dehydrogenase (inhibited by NADPH)
    • reactants: NADP+
    • products:NADPH+H+
    • Irreversable
      **oxidation
  6. 6-Phosphogluconolactone6-Phosphogluconate
    • Enz: Lactonase
    • Reactants:H2O
    • Products:H+
    • Irreversable
    • **Opening of sugar ring
  7. 6-PhosphogluconateRibulose 5-P
    • Enz: 6-Phosphogluconate dehydrogenase
    • Reactants: NADP+
    • Products:NADPH+H++CO2
    • Irreversable
    • **Oxidation and Decarboxilation
  8. 3 uses for Nonreducing part of PPP
    • -production of R5P and not NADPH through reverse pathway
    • -Cyclicle production of NADPH
    • -Production of NADPH and ATP (Glycolosis through PPP)
  9. 7 Sugars of the Non-reducing part of the PPP pathway
    • Ribulose 5-P
    • Ribose 5-P
    • xylulose 5-P
    • sedoheptulose 7-P
    • Erythrose 4-P
    • Glyceraldehyde 3-P
    • Fructose 6-P
  10. Ribulose 5-P  Ribose5-P
    • Enz: Phosphopentose Isomerase
    • Reversable
    • **Aldehyde to Ketose
  11. Ribulose 5-P  Xylulose 5-P
    • Enz: phosphopentose epimerase
    • Reversable
  12. Xylulose 5-P + Ribose 5-P  Glyceraldehyde 3-P + Sedoheptulose 7-P
    • Enz: Transketolase (TPP)
    • Reversable
  13. Xylulose 5-P + Ethrose 4-P  Glyceraldehyde 3-P + Fructose 6-P
    • Enz: Transketolase (TPP)
    • Reversable
  14. Glyceraldehyde + Sedoheptulose  Ethrose 4-P + Fructose 6-P
    • Enz: Transaldolase
    • Reversable

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