Bmsc 230 Glycogen

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Scottygo
ID:
198441
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Bmsc 230 Glycogen
Updated:
2013-02-06 20:28:04
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Bmsc 230 Glycogen
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Bmsc 230 Glycogen
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  1. Glycogen
    • -Highly branched homopolysaccharide made exclusively of glucose
    • -each chain has 12-14 residues
    • -linked by (14) glycosidic linkages, and (16) glycosidic linkage at the branches
    • -Exist as large cytoplasmic granules
    • -the more branches the more soluble it is
  2. Glycogen granule
    -a complex aggregate of of glycogen, enzymes that synthesize and degrade it, and regulatory enzymes.
  3. Glycogen granule consists of approx ______ residues with approx ______ non-reducing ends
    • -55,000
    • -2,000
  4. Pathway from Glucose to Glycogen
    • Glucose
    • (hexokinase)
    • Glucose 6-P
    • (Phosphoglucomutase)
    • Glucose 1-P
    • UDP-Glucose
    • (Gycogen Synthase)
    • Glycogen
  5. Glycogenin activity
    • Enz: glycogenin
    • **adds first 8 UDP-Glucose to Glycogen Granule one at a time adding them to reducing side
    • -UDP pops off when new residue is added
    • -after 8 residues glycogen synthase takes over.
  6. Glycogen synthesis a(1-4)
    • Enz: Glycogen synthase
    • Reactants:glycogen chain + UDP-glucose
    • Products: (Glycogen + 1 residue) + UDP
    • **glucose added to non-reducing side
  7. Glycogen synth a(1-6)
    • Enz: Branching enzyme (a(1-6) glucose transferase)
    • ** new branch is created and then broken off 4 residues past the last branch point. 
    • -it is then added to said branch 4 residues up
  8. Pathway from Glycogen to Glucose
    • Glycogen
    • (Glycogen Phosphorylase)
    • Glucose 1-P
    • (Phosphoglucomutase)
    • Glucose 6-P
    • (hexokinase)
    • Glucose
  9. Glycogen  Glucose 1-P
    • Enz: Glycogen phosphorylase
    • reactants:Pi
    • products: Glucose 1-P + (Glycogen chain - 1 residue)
  10. Steps in Degradation of Glycogen
    • -residues broken off one at a time until 4 residues till branch point
    • -3 of remaining residues are broken off by:
    • enzyme: 4-a-Glucanotransferase
    • and attached to end of preceding chain
    • -last residue broken off by debranching enzyme
  11. Glycogen synthase inhibited by
    • Glycogen synthase kinase 3 (GSK-3)
    • **phosphorylates GS
    • -requires ATP
  12. Glycogen Phosphorylase Activated by
    • -Phosphorylase Kinase
    • **phosphorylates GP
  13. What molecules inhibit Glycogen degradation?
    • High energy molecules
    • -glucose
    • -ATP
  14. What molecules activate Glycogen degradation?
    • low energy molecules
    • -AMP
  15. What molecules activate Glycogen synth?
    • -G6P
    • -Insulin

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