Bacteria Toxins

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Author:
Anonymous
ID:
198637
Filename:
Bacteria Toxins
Updated:
2013-02-07 08:23:06
Tags:
bacteria
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Description:
bacteria
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  1. C. diptheriae
    • Diptheria toxin
    • inactivates EF-2 via ribosylation, thus inhibiting host cell protein synthesis
  2. P aeruginosa
    • Exotoxin A
    • Inactivates EF-2 via ribosylation, thus inhibiting host cell protein synthsis
  3. S. aureus
    • Enterotoxin: superantigen that acts locally on the GI tract --> vomiting
    • TSS toxin: superantigen that stimulates T-cells leading to widespread cytokine release & shock
  4. C. difficle
    • Cytotoxin B
    • Induces actin depolymerization leading to mucosal death, necrosis of colonic mucosal surfaces & pseudomembrane formation
  5. C. botulinum
    • Botulinum toxin
    • Blocks the presynaptic release of Ach at the neuromuscular junction resulting in flaccid paralysis
  6. B pertussis
    • Pertussis toxin
    • Disihibits adenylate cyclase via Gi ADP ribosylation, increasing cAMP production in the host cells, causes increased histamine sensitivity & phagocyte dysfunction
  7. V. cholerae
    • Cholerae toxin
    • Activates adenylate cyclase via Gs ADP ribosylation, increasing cAMP production in the host cell, secretory diarrhea, dehydration & electrolyte imbalance

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