Used for treatment of Bipolar Disorder. Reduces or eliminates mania, suppresses mood swings.
What is Lithium's mode of action?
Thought to relate to reuptake of serotonin and norepinephrine. No one knows for sure.
What are Lithium's side effects?
Nausea, fine hand tremor, polyuria (excessive passage of urine), polydipsia(chronic excessive thirst).
What is the major danger of Lithium?
Toxicity-- specifically if dose is too high.
What are symptoms of Lithium toxicity?
Diarrhea, nausea, vomiting, sedation, slurred speech, confusion, coarse tremor, loss of coordination. Can lead to seizures, coma, death.
When is Lithium contraindicated?
When blood sodium levels are unpredictable (do not use caffeine, alcohol, diuretics); persons with cardiovascular, kidney, liver, thyroid, or gastrointestinal problems.
What is the primary use of Carbamazepine?
As an anti-convulsant. Use as a mood stabilizer is secondary.
What is Carbamazebine's trade / brand name?
What are other drugs with secondary uses as mood stabilizers?
Valproic acid (Depakote) and Clonazepam (Klonopin).
What are the uses of Carbamazepine?
Useful for treating Bipolar Disorder, particularly among those who have not responded to Lithium. May be most beneficial for persons with frequent / rapid mood swings and persons with dysphoric mania.
What is Carbemazepine's mode of action?
Believed to affect serotonin levels; no one knows for sure.
What are the side effects of Carbemazepine?
Dizziness, ataxia (loss of ability to coordinate muscle movement), visual disturbances, anorexia, nausea, rash.
What is the major danger of Carbamazepine?
Effects on cardiovascular functioning. Contraindicated for persons with abnormalities in cardiac conduction; slight risk of agranulocytosis (high fever and sharp drop in circulating white blood cells) and aplastic anemia (failure of bone marrow to create red and white blood cells).