Endomembrane and Protein Trafficking

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Endomembrane and Protein Trafficking
2013-02-08 03:13:04
Cell Mol

Cell Mol
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  1. functionally and structurally interrelated group
    of membranous cytoplasmic organelles including the endoplasmic reticulum, Golgi
    complex, endosomes, lysosomes, and vacuoles 
    Endomembrane System
  2. a protein-lined channel embedded in the ER
    membrane; the nascent polypeptide in able to move through the translocon in its
    passage from the cytosol to the ER lumen
  3. the step in translation elongation cycle that
    involves 1) ejection of the uncharged tRNA from the P site and 2) the movement
    of the ribosomes three nucleotides (one codon) along the mRNA in the 3’
  4. a family of small RNAs that rate the information
    encoded in the nucleotide “alphabet” of the polypeptide 
  5. portion of a membrane protein that passes
    through the lipid bilayer, often composed of non-polar amino acids in an
    alpha-helical conformation
    Transmembrane domain
  6. the shuttles, formed by budding from a membrane
    compartment, that carry material between organelles 
    Vesicular Transport
  7. transfer of information across plasma membrane
    Transmembrane signaling
  8. route through the cytoplasm by which materials
    are synthesized in the endoplasmic reticulum and Golgi complex, modified during
    passage through Golgi complex, and transported within the cytoplasm to various
    destinations such as PM, lysosome, or a large vacuole of a plant cell
    Secretory Pathway (biosynthetic pathway)
  9. material synthesized in the ER or Golgi complex
    are discharged outside of the cell 
    Secretory Pathway
  10. discharge of materials synthesized in the cell
    that have been stored in membrane-bound secretory granules in the peripheral
    regions of the cytoplasm, occurring in response to an appropriate stimulus
    Regulated Secretory Pathway
  11. any substance that can bind to a specific
    molecule ligand often leading to uptake or signal transduction 
  12. discharge of material synthesized in the cell
    into the extracellular spave in a continual manner 
    Regulated Secretory Pathway
  13. any substance that can bind to a specific
    molecule ligand often leading to uptake or signal transduction 
  14. discharge of material synthesized in the cell
    into the extracellular space in a continual manner 
    Constitutive Secretion
  15. the information superhighways of the cell. Each
    consists of a series of distinct proteins that operate in sequence . Each
    protein in the pathways acts by altering the conformation of the downstream
    protein in the series
    Signaling pathways
  16. series of amino acids located at the N- terminal
    portion of newly forming proteins that triggers the attachment of the
    protein-forming ribosomes to an ER membrane and the movement of the nascent
    polypeptide into the cisternal space of the ER
    Signal Sequence
  17. overall process in which information carried by
    extracellular messenger molecules is translated into changes that occur within
    the cell
    Signal Transduction
  18. the reaction by which sugar groups are added to
    proteins and lipids
  19. key proteins that mediate the process of membrane
  20. located in the membrane of the target compartment
  21. incorporate into membrane of transport vesicles during budding
  22. flattened sacs separated by cystolic space
  23. signal recognition particle, binds to both
    signal sequence and on polypeptide and ribosome
  24. - acts as an address label, at the N ternminus

    Signal peptidase- cut off signal sequence upon

    Signal patches- surface

    Recognized at 3D structure

    Retain final functional
    Sorting signal
  25. bind and transport phospholipids through aqueous
    cytosol from one membrane compartment to next
    Phospholipid-transfer protein
  26. -enzymes facilitate movement of
    specific phospholipids from ER to other organelles

    -important in delivering lipid to
    Phospholipid-transfer protein