Antifungal - Amphotericin B .txt
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How does Amphotericin B work?
Forms pores in fungal membranes which contain ergosterol but not in cholesterol-containing membranes
What are the effects of Amphotericin B?
Loss of intracellular contents through pores (fungicidal)
What are the clinical applications of Amphotericin ?
What kinds of illnesses does Amphotericin B treat?
- Fungal meningitis (intrathecal)
- Bladder & ocular infections (topical)
What kind of adverse effects does Amphotericin B have?
- Renal impairment
- Liver failure
What kind of macrolide is Amphotericin B?
Does Amphotericin work in CSF?
What 2 types of adverse effects can occur with Amphotericin?
Immediate & Delayed
What do we do help with nephrotoxity of Amphotericin B?
give a pre & post bolus of NS
What kinds of delayed reactions do you see with Amphotericin B?
renal damage & liver FX abnormality
What would you like to do?
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