Antifungal - Azoles.txt

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Author:
drtrouta
ID:
198791
Filename:
Antifungal - Azoles.txt
Updated:
2013-02-07 21:16:36
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Antifungal Azoles
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Antifungal - Azoles.txt
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  1. ´╗┐What are the 2 classess of Azoles?
    • Imidazoles
    • Triazoles
  2. How do Azoles work?
    reduces ergosterol synthesis by inhibition of fungal cytochrom P450 enzymes
  3. How many carbons does Imidazoles have?
    2
  4. How many carbons does Triazoles have?
    3
  5. Are Azoles broad spectrum?
    Yes
  6. What can Azoles treat that Amphotericin can't?
    P boydii
  7. What are adverse effects of Azoles?
    relatively nontoxic - GI upset, liver enzyme abnormality
  8. Which class of Azoles interferes with CP450?
    Imidazoles
  9. What class of antifungals does Ketoconazole belong to?
    Azoles
  10. What class of antifungals does Itraconzole belong to?
    Azoles
  11. What is the MOA for Ketoconazole?
    Blocks fungal P450 enzymes & interferes with ergosterol synthesis
  12. What is the MOA for Itraconazole?
    Blocks fungal P450 enzymes & interferes with ergosterol synthesis
  13. Which is more selective? Ketoconazole or Itraconazole
    Itraconazole
  14. Why is Ketoconazole not given IV?
    Due to toxicity (used as topical only)
  15. What is a toxicity/interaction of Ketoconazle?
    Interferes with steroid hormone synthesis & Pahse I drug metabolism
  16. Does Itraconazole have a high or low toxicity?
    • Low
    • What does Itraconazole treat?
    • Candida
    • Cryptococcus
    • Blastomycosis
    • Coccidioidomycosis
    • Histoplasmosis
  17. Of Ketoconazole, Itraconazole, or Fluconazole, which is only given orally?
    Ketoconazole
  18. Of Ketoconazole, Itraconazole, or Fluconazole, which is eliminated renally?
    Fluconazole
  19. How are Ketoconazole & Itraconazole eliminated?
    hepatically

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