Flouroquinolones.txt

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Author:
drtrouta
ID:
198796
Filename:
Flouroquinolones.txt
Updated:
2013-02-07 21:25:40
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Flouroquinolones
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Flouroquinolones.txt
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  1. What is the MOA for flouroquinolones?
    DNA gyrase inhibitor (Topoisomerase II/IV)
  2. What treats atypical PNA?
    flouroquinolones
  3. What types of bacteria does flouroquinolones treat?
    • Gram – aerobic (primarily)
    • Gram + (newer agents)
  4. Which flouroquinolone is not excreted via renal?
    Moxifloxacin
  5. If you give Moxifloxacin, do you need to adjust the dose for a CC<50?
    No, not excreted via renal
  6. At what point does the dosage of flouroquinolone need to be adjusted?
    CC<50ml/min (except Moxifloxacin)
  7. Does flouroquinolone cross the placenta?
    Yes
  8. What pregnancy category is flouroquinolones?
    C
  9. What 3 things causes resistance to flouroquinolones?
    • Mutations (binding region of target enzyme & change in permeability of the organism)
    • Overuse of the agents (staph, strep, and enterococcus developed resistance)
    • Cross resistance to other quinolones
  10. When should fluroquinolones be used?
    Only when needed
  11. What are fluroquinolones used to treat?
    • UTI
    • Multi-drug resistant bacteria
    • Bacterial diarrhea (salmonella, e. coli)
    • Bones, joints, soft-tissues
    • Atypical PNA
  12. Are fluroquinolones used to treat gonococcal infections?
    No
  13. What is the choice tx/prophylaxis of anthrax?
    Fluroquinolones
  14. What are the adverse side effects of fluroquinolones?
    • GI
    • QT interval prolongation
    • Tendon rupture
    • Risk for SZ
  15. What 3 things does fluroquinolones have a Black Box warning on?
    • Myasthenia gravis
    • Tendonitis
    • Tendon rupture
  16. What Patient group is contraindicated in using fluroquinolones?
    <18 years
  17. What kind of drug is Ciprofloxacin?
    Fluoroquinolone
  18. What is the MOA of Cipro?
    Inhibits DNA replication by binding to DNA gyrase & topoisomerase IV
  19. What does Cipro treat?
    • UTI’s
    • Gastroenteritis
    • Osteomyelitis
    • Anthrax
  20. How does Cipro toxicity manifest?
    • GI upset
    • Neurotoxicity
    • Tendonitis

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