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What is the MOA for flouroquinolones?
DNA gyrase inhibitor (Topoisomerase II/IV)
What treats atypical PNA?
What types of bacteria does flouroquinolones treat?
- Gram – aerobic (primarily)
- Gram + (newer agents)
Which flouroquinolone is not excreted via renal?
If you give Moxifloxacin, do you need to adjust the dose for a CC<50?
No, not excreted via renal
At what point does the dosage of flouroquinolone need to be adjusted?
CC<50ml/min (except Moxifloxacin)
Does flouroquinolone cross the placenta?
What pregnancy category is flouroquinolones?
What 3 things causes resistance to flouroquinolones?
- Mutations (binding region of target enzyme & change in permeability of the organism)
- Overuse of the agents (staph, strep, and enterococcus developed resistance)
- Cross resistance to other quinolones
When should fluroquinolones be used?
Only when needed
What are fluroquinolones used to treat?
- Multi-drug resistant bacteria
- Bacterial diarrhea (salmonella, e. coli)
- Bones, joints, soft-tissues
- Atypical PNA
Are fluroquinolones used to treat gonococcal infections?
What is the choice tx/prophylaxis of anthrax?
What are the adverse side effects of fluroquinolones?
- QT interval prolongation
- Tendon rupture
- Risk for SZ
What 3 things does fluroquinolones have a Black Box warning on?
- Myasthenia gravis
- Tendon rupture
What Patient group is contraindicated in using fluroquinolones?
What kind of drug is Ciprofloxacin?
What is the MOA of Cipro?
Inhibits DNA replication by binding to DNA gyrase & topoisomerase IV
What does Cipro treat?
How does Cipro toxicity manifest?
- GI upset