Card Set Information
What is the MOA for flouroquinolones?
DNA gyrase inhibitor (Topoisomerase II/IV)
What treats atypical PNA?
What types of bacteria does flouroquinolones treat?
Gram – aerobic (primarily)
Gram + (newer agents)
Which flouroquinolone is not excreted via renal?
If you give Moxifloxacin, do you need to adjust the dose for a CC<50?
No, not excreted via renal
At what point does the dosage of flouroquinolone need to be adjusted?
CC<50ml/min (except Moxifloxacin)
Does flouroquinolone cross the placenta?
What pregnancy category is flouroquinolones?
What 3 things causes resistance to flouroquinolones?
Mutations (binding region of target enzyme & change in permeability of the organism)
Overuse of the agents (staph, strep, and enterococcus developed resistance)
Cross resistance to other quinolones
When should fluroquinolones be used?
Only when needed
What are fluroquinolones used to treat?
Multi-drug resistant bacteria
Bacterial diarrhea (salmonella, e. coli)
Bones, joints, soft-tissues
Are fluroquinolones used to treat gonococcal infections?
What is the choice tx/prophylaxis of anthrax?
What are the adverse side effects of fluroquinolones?
QT interval prolongation
Risk for SZ
What 3 things does fluroquinolones have a Black Box warning on?
What Patient group is contraindicated in using fluroquinolones?
What kind of drug is Ciprofloxacin?
What is the MOA of Cipro?
Inhibits DNA replication by binding to DNA gyrase & topoisomerase IV
What does Cipro treat?
How does Cipro toxicity manifest?