Card Set Information
What is the Moa kind of sulfonamides/pyrimidines?
What kind of effect does sulfonamides/pyrimidines have?
Which enzyme does sulfonamides compete against PABA for?
Which enzyme does pyrimidines (Trimethoprim) work on?
What does sulfonamides compete with for dihydropteroate synthase?
What are the 3 major groups of sulfonamides?
Oral absorbable (Bactrim DS)
Oral nonabsorbable (sulfasalazine)
Topical (Silvadene cream)
What are the clinical uses of sulfonamides?
use early on
use in combination with topical agents
What are the adverse effects of sulfonamides?
fever, rash, photosensitivity, urticaria, GI upset
UTI problems (drink lots of fluids with)
Hematopoietic Problems (glucose-6-phosphate dehydrogenase deficiency)
which helps with production of RBC's
Kernicterus in newborns if given during pregnancy (elevated bilirubin that causes neuro effects)
What is Stevens-Johnson Syndrome?
systemic reaction to a med in which the mucous membranes slough off
What is Trimethoprim & Trimethoprim-Sulfamethoxazole (TMP-SMZ) Moa?
synergistic combo of folate antagonists that blocks purine production & nucleic acid synthesis
What is the pk of TMP-SMZ?
given as 1:5 ratio
reduce in renal failure
Pregnancy Category C if given late in pregnancy
Concentrates in prostatic/vaginal fluids
excreted in breast milk
Contraindicated in infants <2 months
What are uses of oral TMP-SMZ?
resistant pneumococci & E. coli
What are the uses for IV TMP-SMZ?
pneumocystitis PNA (agent of choice)
What other things does TMP-SMZ treat?
What are the adverse effects of TMP-SMZ?
rash, urticaria, photosensitivity, GI upset,
bone marrow suppression
partial cross allergy w/ diuretics, diazoxide, sulfonylurea hypoglycemic agents
AIDS Pt's have worse reactions
What is the adverse effects of Trimethoprim alone?
What is the Moa of Flouroquinolones?
Inhibition of DNA gyrase (Toposomerase II/IV) so bacteria can't reproduce
What is chemistry of flouroquinolones?
synthetic fluorinated analogs of nalidixic acid
What is the pk of flouroquinolones?
blocks bacterial DNA synthesis
dosage adjustment if CC<50 ml/min (except Moxifoaxacin)
Crosses the placenta
Pregnancy Category C
Divalent & trivalent cation products can impair oral absorption
What is flouroquinolones used for?
bacterial diarrhea (salmonella, E. coli)
bones, joints, soft-tissues, intra-abdominal
Which antibiotic is not longer recommended to treat gonococcal infections?
Which flouroquinolone is the DOC for tx/prophylaxis of anthrax?
What is Levofloxacin known as?
respiratory fluroquinolone (pneumococcus)
What are adverse effects of flouroquinolones?
QT interval prolongation
Not for Pt <18 yrs
risk for Sz
Which antibiotic has a Black Box warning for myasthena gravis, tendonitis, & tendon rupture?