Pyruvate Dehydrogenase Complex Reaction

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Author:
Scottygo
ID:
198816
Filename:
Pyruvate Dehydrogenase Complex Reaction
Updated:
2013-02-07 23:04:56
Tags:
Pyruvate Dehydrogenase Complex Reaction
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Description:
Pyruvate Dehydrogenase Complex Reaction
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  1. Enzymes(3)
    • Pyruvate dehydrogenase
    • dihydrolipoyl transacetylase
    • dihydrolipoyl dehydrogenase
  2. Cofactors
    • -thiamine pyrophosphate (TPP)
    • -Lipoic Acid
    • -Coenzyme A
    • -Nicotinamide Adenine Dinucleotide(NAD+)
  3. pyruvate dehydrogenase
    • -decarboxylation of pyruvate
    • -oxidation of hydroxyethel intermediate
    • -transfer of 2 C to TPP
  4. dihydrolipoyl transacetylase
    • transfer of acetyl group to Co-A producing Acetal CoA
    • -sulfur of lipyol group is reduced
  5. Dihydrolipoyl dehydrogenase
    -Fad+ oxidizes sulfur from lipoyl group
  6. Last step
    -FADH2 is oxidized by NAD+ back to FAD+

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