Hematology Ch. 16

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Hematology Ch. 16
2013-02-09 22:59:25
Leukocytes Lymphs Plasma Cells

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  1. Lymphocytes and plasma cells are responsible for:
    • Recognition of foreign antigens
    • Antibody protection
  2. Lymphocytes originate from:
    Stem Cells in bone marrow
  3. B-lymphs responsible for:
    Antibody synthesis
  4. T-lymphs responsible for:
    Antigen recognition
  5. Bone marrow and thymus gland are known as the __________ Lymphoid tissues.
  6. Lymph nodes, spleen, Peyer's Patch are known as ___________ Lymphoid tissues.
  7. Lymphocyte recirculation:
    Lymphs move freely between peripheral blood and lymphoid tissues.
  8. Lymphocyte
  9. Only ____________ lymphocytes are normally seen in peripheral blood.
  10. Most "small" lymphs are ____ lymphs.
  11. Most "large" lymphs are _____ lymphs
  12. T or F. The Wright Stain can accurately differentiate between T and B lymphs.
  13. _____% of peripheral lymphocytes may be morphologically abnormal
  14. Variant Lymphocytes have been immunologically stimulated and have _________ DNA/RNA activity.
  15. They are associated with viral infections, such as:
    IM, viral pneumonia, and hepatitis
  16. General characteristics of Variant Lymphocytes:
    • Large overall size.
    • Large, irregular (oval, lobulated, folded) nucleus
    • Abundant, smooth, light gray to dark blue cytoplasm.
    • "Sticky" often have adjacent RBCs.
    • Peripheral basophilia
    • Vacuoles and azurophilic granules may be present.
  17. Atypical lymphocyte
  18. Bi-nucleated lymphocytes are associated with:
  19. Rieder cells (clover leaf nuclei) are associated with:
  20. Vacuolated lymphs are associated with:
    • Viral infection
    • Chemotherapy
    • Irradiation
  21. Smudge cells (broken cells) are associated with:
    CLL, artifact
  22. T-Lymphs (cellular immunity) functions and membrane characteristics:
    Antigen recognition and B-lymph regulation
  23. B-lymphs (Humoral immunity) are associated with:
    • Antibody production
    • A mature, activated B-lymph is a plasma cell
  24. NK
    • Cytotoxic reactions
    • Stimulated by interferon and kill virus infected cells
  25. K-type lymphocytes
    Kill cells coated with IgG antibody
  26. Lymphs have specific receptor sites on their membranes that:
    Regulate their immune responses
  27. These various receptor sites are used to:
    classify the various lymph subgroups
  28. T-lymphs are classified into 2 subgroups:
    • Suppresor/Cytotoxic (CD8)=inhibits B-lymph activity.
    • Helper/Inducer (CD4)=Stimulated B-lymph activity
  29. What is the normal helper/suppressor ration?
    • 2:1
    • It is utilized to evaluate HIV patients.
  30. A helper/suppressor=0.5 indicates:
    poor immune status
  31. Plasma cells are mature, stimulated B-lymphs, actively synthesizing antibody.
    Plasma cells should be ID as plasma cells on the WBC differential
  32. Plasma cell development:
    • B lymph (creates antibodies)
    •         Blast Transformation
    •         Antigenic stimulation
    •         T-Helper Cell Stimulation
    • Plasma Cell
  33. Plasma Cell characterisitics:
    • Large cell
    • Large, dark blue, condensed, eccentric nucleus.
    • Basophilic cytoplasm
    • Perinuclear halo (light area around nucleus)
  34. Plasma Cell
  35. Plasma Cell
  36. Plasma Cell