Hematology Ch. 16
Card Set Information
Hematology Ch. 16
Leukocytes Lymphs Plasma Cells
Lymphocytes and plasma cells are responsible for:
Recognition of foreign antigens
Lymphocytes originate from:
Stem Cells in bone marrow
B-lymphs responsible for:
T-lymphs responsible for:
Bone marrow and thymus gland are known as the __________ Lymphoid tissues.
Lymph nodes, spleen, Peyer's Patch are known as ___________ Lymphoid tissues.
Lymphs move freely between peripheral blood and lymphoid tissues.
Only ____________ lymphocytes are normally seen in peripheral blood.
Most "small" lymphs are ____ lymphs.
Most "large" lymphs are _____ lymphs
T or F. The Wright Stain can accurately differentiate between T and B lymphs.
_____% of peripheral lymphocytes may be morphologically abnormal
Variant Lymphocytes have been immunologically stimulated and have _________ DNA/RNA activity.
They are associated with viral infections, such as:
IM, viral pneumonia, and hepatitis
General characteristics of Variant Lymphocytes:
Large overall size.
Large, irregular (oval, lobulated, folded) nucleus
Abundant, smooth, light gray to dark blue cytoplasm.
"Sticky" often have adjacent RBCs.
Vacuoles and azurophilic granules may be present.
Bi-nucleated lymphocytes are associated with:
Rieder cells (clover leaf nuclei) are associated with:
Vacuolated lymphs are associated with:
Smudge cells (broken cells) are associated with:
T-Lymphs (cellular immunity) functions and membrane characteristics:
Antigen recognition and B-lymph regulation
B-lymphs (Humoral immunity) are associated with:
A mature, activated B-lymph is a
Stimulated by interferon and kill virus infected cells
Kill cells coated with IgG antibody
Lymphs have specific receptor sites on their membranes that:
Regulate their immune responses
These various receptor sites are used to:
classify the various lymph subgroups
T-lymphs are classified into 2 subgroups:
Suppresor/Cytotoxic (CD8)=inhibits B-lymph activity.
Helper/Inducer (CD4)=Stimulated B-lymph activity
What is the normal helper/suppressor ration?
It is utilized to evaluate HIV patients.
A helper/suppressor=0.5 indicates:
poor immune status
Plasma cells are mature, stimulated B-lymphs, actively synthesizing antibody.
Plasma cells should be ID as plasma cells on the WBC differential
Plasma cell development:
B lymph (creates antibodies)
T-Helper Cell Stimulation
Plasma Cell characterisitics:
Large, dark blue, condensed, eccentric nucleus.
Perinuclear halo (light area around nucleus)