Compare prokaryotes to Eukaryotes.
Eukaryotes are larger, have a nucleus and membrane-bound organelles. Prokaryotes are more chemically complex, have no cytoskeleton or cytoplasm and have smaller ribosomes. Prokaryotes have a single circular DNA lacking histones, eukaryotes have multiple linear chromosomes with histones. Eukaryotes divide by mitosis, prokaryotes by binary fission and eukaryotes sexually reproduce by meiosis.