1. Who can make vit C? from what pathway? (write substrate, metabolite, and product)
2. As dosage increases, how does bioavailability change? What happens if you take too much Vitamin C?
How is vitamin C status assessed?
1. Most animals (except us, guinea pigs, birds, bats, most fish) from glucose and all plants from glucose --> glucuronic acid --> vitamin C
2. As dosage increases, bioavailability decreases (at normal levels, almost totally used, at high doses 1000 mg - only 50% absorbed)
Osmotic diarrhea (not absorbed), chewable tablets can harm teeth.
Via plasma vitamin C levels