Tablets

Card Set Information

Author:
jcu1
ID:
199973
Filename:
Tablets
Updated:
2013-02-12 09:10:33
Tags:
DD3 exam
Folders:

Description:
Dr. Sant
Show Answers:

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  1. Diluents + examples
    • improve compressibility, flow, and inc bulk
    • lactose
    • microcrystalline cellulose
    • mannitol
    • dicalcium phosphate
  2. Binders + examples
    • enhance compressibility
    • polyvinyl pyrrolidone
    • hypromalose
    • starch paste
  3. disintegrant + examples
    • facillitates break down of tablet
    • water swellable: starch
    • super disintegrants: cross-linked povidone, croscarmalose sodium, sodium starch glycolate
  4. lubricants + examples
    • prevent tablet ticking to punches and cavities
    • Mg stearate
    • stearic acid
    • talc
    • sodium stearate fumarate
  5. glidants + examples
    • improve flow
    • colloidal silicone dioxide
    • talk
  6. wetting agents + examples
    • facilitates dissolution
    • sodium laurel sulfate
    • polysobate 20
    • tween 80
  7. manufacturing method of wet granulation
    • 1. blending
    • 2. granulation with solvent
    • 3. granulation
    • 4. milling
    • 5. final blending (milling)
    • 6. compression
  8. manufacturing method of dry granulation
    • 1. blending
    • 2. compaction and slugging
    • 3. milling
    • 4. final blending (mixing)
    • 5. compression
  9. agglomeration
    used to enlarge size by bringing the particles together through addition of granulation liquid that forms capillary action
  10. dry granulation
    • roller compactor (counter rotating rollers, milling)
    • slugging (tabs created and then crushed again - less common)
  11. wet granulation
    • high shear granulator
    • fluid bed granulator (top, bottom, and tangent spray granulators)
  12. types of blending
    • rotating blenders: bin blender, V blender
    • fixed shell blenders: (ribbon blenders)
  13. compression
    • single station press: small scale, automatic or semiautomatic
    • rotary compression press: large scale, automatic, uses a gravity or force feeder
  14. tablet defects
    • picking and sticking
    • capping (top comes off)
    • lamination (when one part of the tablet expands before the other parts)
    • chipping
    • mottling (not well mixed)
  15. disintegration testing
    • glass tubes with 10 mesh at the bottom
    • with or w/o sinker
    • uncoated tablets should disintegrate in <15 min
  16. friability testing
    • mechanical shock
    • diff in weight before and after 100 rotations
  17. coating equipment
    • standard coating pan
    • perforated coating pan
    • fluidized bed coater

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