Tablets

• improve compressibility, flow, and inc bulk
• lactose
• microcrystalline cellulose
• mannitol
• dicalcium phosphate

• enhance compressibility
• polyvinyl pyrrolidone
• hypromalose
• starch paste

• facillitates break down of tablet
• water swellable: starch
• super disintegrants: cross-linked povidone, croscarmalose sodium, sodium starch glycolate

• prevent tablet ticking to punches and cavities
• Mg stearate
• stearic acid
• talc
• sodium stearate fumarate

• improve flow
• colloidal silicone dioxide
• talk

• facilitates dissolution
• sodium laurel sulfate
• polysobate 20
• tween 80

• 1. blending
• 2. granulation with solvent
• 3. granulation
• 4. milling
• 5. final blending (milling)
• 6. compression

• 1. blending
• 2. compaction and slugging
• 3. milling
• 4. final blending (mixing)
• 5. compression

used to enlarge size by bringing the particles together through addition of granulation liquid that forms capillary action

• roller compactor (counter rotating rollers, milling)
• slugging (tabs created and then crushed again - less common)

• high shear granulator
• fluid bed granulator (top, bottom, and tangent spray granulators)

• rotating blenders: bin blender, V blender
• fixed shell blenders: (ribbon blenders)

• single station press: small scale, automatic or semiautomatic
• rotary compression press: large scale, automatic, uses a gravity or force feeder

• picking and sticking
• capping (top comes off)
• lamination (when one part of the tablet expands before the other parts)
• chipping
• mottling (not well mixed)

• glass tubes with 10 mesh at the bottom
• with or w/o sinker
• uncoated tablets should disintegrate in <15 min

• mechanical shock
• diff in weight before and after 100 rotations

• standard coating pan
• perforated coating pan
• fluidized bed coater