Capsules

Card Set Information

Author:
jcu1
ID:
200050
Filename:
Capsules
Updated:
2013-02-12 22:14:28
Tags:
DD3 exam
Folders:

Description:
Dr. Sant
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user jcu1 on FreezingBlue Flashcards. What would you like to do?


  1. bloom strength
    measure of gel rigidity 
  2. hydroxypropyl methylcellose 
    • vegetable
    • low moisture content
    • more soluble
  3. components of softgel manufacturing
    • 1. gel mass
    • 2. fill formation
    • 3. encapsulation
    • 4. drying
    • 5. finishing
  4. gell mass (shell formation) - what are the shells made of?
    • gelatin: animal skin and bones
    • plasticizers: water, glycerin, sorbitol, partially dehydrated sorbitol, propylen glycol, mannitol
    • water
    • opacifiers: titanium dioxide
    • colorants, flavors, sweeteners, preservatives
  5. tests performed on gelatin
    • bloom test
    • iron content
    • viscosity
    • microbiology
  6. plasticizers - what they do
    • reduce the glass transition temp
    • reduce protein-protein interactions
    • increase protein chain motility
  7. plasticizer examples
    • glycerin - low MW, high hygroscopicity, low Tg
    • sorbitol
    • matitiol
    • low MW PEGs
  8. colorant examples
    • dyes: water soluble
    • lakes: insoluble forms of a dye
    • in organic pigments (titanium dioxide)
    • natural colorants (riboflavin)
  9. opacifier examples
    • titanium dioxide
    • light resistant
    • used for things with an unaesthetic fill
    • 0.5-1% by weight of shell
  10. things that cause crosslinking
    • high temp, humidity
    • UV and gamma radiation
    • rapid drying
    • aldehydes, ketones
    • imines, carbodiimides
  11. hydrophilic vehicles for softgel capsules
    • PEGs of low MW's
    • MPEGs (methoxy-PEGs)
    • glycofurol
    • ethyl alcohol (may diffuse and carry out other fill components)
    • water, glycerine, propylene glycol (may act as a plasticizer for the shell)
  12. lipophilic vehicles for softgel capsules
    • free fatty acids
    • ethyl alcohol
    • propylene glycol
    • glycerin
    • sorbitol/sucrose
    • polyethoxylated fatty acid esters
  13. drying the softgel capsules
    • primary drying - tumbler drying
    • secondary drying - tray drying process

What would you like to do?

Home > Flashcards > Print Preview