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Med Chem III Exam #1
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Azoles
appears to inhibit fungal CYP450 enzymes responsible for fungal sterol biosynthesis, lanosterol 14 alpha-demethylase
Allylamines
inhibits squalene 2,3-epoxidase in the ergosterol pathway which leads to the buildup of squalene damaging cell membranes
Polyenes
appear to bind cell wall sterols leading to disruption of the membrane and loss of K+
Griseofulvin
binds tubulin dimer and prevents microtubule formation by causing dissolution of mitotic spindle apparatus leading to arrest of cell division
Phenol and derivatives
acts on cell membranes and blocks amino acid transport into cell
Fatty acids
disruption of cell membranes
Nucleoside -- Flucytosine
incorporated in RNA, deaminated to 5-fluorouracil leading to inhibition of thymidylate synthetase
Glucan synthesis inhibitors
inhibit the synthesis of beta (1,3)-D-glucan an integral component of the fungal cell wall
Gentian violet
disruption of cell walls
Hlaoprogin – Halotex
inhibit DNA replication
Author
mp
ID
200095
Card Set
Med Chem III Exam #1
Description
Med Chem III Exam #1 moa
Updated
2/12/2013, 10:42:24 PM
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