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mp
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Azoles
appears to inhibit fungal CYP450 enzymes responsible for fungal sterol biosynthesis, lanosterol 14 alpha-demethylase
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Allylamines
inhibits squalene 2,3-epoxidase in the ergosterol pathway which leads to the buildup of squalene damaging cell membranes
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Polyenes
appear to bind cell wall sterols leading to disruption of the membrane and loss of K+
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Griseofulvin
binds tubulin dimer and prevents microtubule formation by causing dissolution of mitotic spindle apparatus leading to arrest of cell division
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Phenol and derivatives
acts on cell membranes and blocks amino acid transport into cell
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Fatty acids
disruption of cell membranes
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Nucleoside -- Flucytosine
incorporated in RNA, deaminated to 5-fluorouracil leading to inhibition of thymidylate synthetase
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Glucan synthesis inhibitors
inhibit the synthesis of beta (1,3)-D-glucan an integral component of the fungal cell wall
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Gentian violet
disruption of cell walls
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Hlaoprogin – Halotex
inhibit DNA replication
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