Med Chem III Exam #1

appears to inhibit fungal CYP450 enzymes responsible for fungal sterol biosynthesis, lanosterol 14 alpha-demethylase

inhibits squalene 2,3-epoxidase in the ergosterol pathway which leads to the buildup of squalene damaging cell membranes

appear to bind cell wall sterols leading to disruption of the membrane and loss of K+

binds tubulin dimer and prevents microtubule formation by causing dissolution of mitotic spindle apparatus leading to arrest of cell division

acts on cell membranes and blocks amino acid transport into cell

disruption of cell membranes

incorporated in RNA, deaminated to 5-fluorouracil leading to inhibition of thymidylate synthetase

inhibit the synthesis of beta (1,3)-D-glucan an integral component of the fungal cell wall

disruption of cell walls

inhibit DNA replication