The flashcards below were created by user
wcameron
on FreezingBlue Flashcards.
-
Normal Cholesterol Levels
- TC < 200
- LDL <100
- HDL > 40 men, > 50 women
- TG <150
-
Non-HDL-C goal
30 more than the LDL-C goal
Calculate by (TC - HDL-C = non-HDL-C)
-
1st line treatment for dyslipidemia
Statin therapy
-
ATP III Risk Stratification for Dyslipidemia goals: Low risk (0-1 risk factor)
LDL-C goal < 160
-
ATP III Risk Stratification for Dyslipidemia goals: Mod. risk (2+ risk factors)
If 10-year Framingham risk is < 10%:
LDL-C goal < 130
-
ATP III Risk Stratification for Dyslipidemia goals: Mod./High risk (2+ risk factors)
If 10-yr. Framingham risk is 10-20%:
LDL-C goal <130, but <100 option
-
ATP III Risk Stratification for Dyslipidemia goals: High risk (3+, CHD, or CHD equivalent risk factor)
LDL-C goal <100, option <70
-
ATP III CHD risk equivalents
DM, Carotid artery disease, AAA, PVD/PAD, or Multiple risk factors (FRAS >20%)
-
ATP III Cholesterol Screening
Begin at age 20, q5y if normal. Annually if abnl.
-
ATP III goals for cholesterol treatment
Target LDL first, then non-HDL-C (which targets TG's).
* Unless TG's dangerously high (>500), then start with TG treatment.
-
Framingham Traditional Risk Factors affecting LDL-C goals
Smoking, Age (men >/= 45, women >/= 55), HTN (>/= 140/90 or on meds), low HDL-C, Fm Hx of premature CHD (male <55y, female <65y)
-
Definition of Myopathy (in consideration of statin therapy)
c/o myalgia, weakness, cramps
+ CK >10x ULN
-
Definition of rhabdomyolosis (in consideration of statin therapy)
CK > 10,000 or > 10x ULN
+
Increased creatinine or need for IV hydration
OBTAIN BASELINE CK IN HIGH RISK PATIENTS (liver dz, renal dz, polypharmacy)
-
Statins
-statin
lower LDL by 30-55%, Crestor best, then Lipitor
Risk of myopathy/rhabdo./liver fx but no need for routine monitoring of LFT's once initiated.
Contraind. in pregnancy, concurrent liver dz
-
"Rule of 6"
Expect 6% reduction in LDL-C with each doubling of statin dose.
|
|