Pharmocology exam 1

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Pharmocology exam 1
2013-02-13 20:19:00
UL Lafayette

Nurs 309
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  1. Prototype Nonselective adrenergic agonist
  2. Prototype alpha 1 adrenergic agonist
  3. Prototype alpha 2 adrenergic agonist
  4. Prototype beta adrenergic agonist
  5. Prototype beta 1 agonist
  6. Prototype dopaminergic agonist
  7. Prototype Alpha antagonist
  8. Prototype beta blocker
  9. Sympathetic/ Adrenergic system responsible for Fight or flight will :
    • Increased heart rate
    • dilate pupils
    • mobilize energy
    • redirect bloodflow from nonessential organs to skeletal muscles
  10. Postganglionic neurotransmitter that is produced and store in the presynaptic nerve terminals of the SNS
  11. Hormone converted from norepinephrine in the adrenal Medulla, also known as adrenaline
  12. Epinephrine was stimulate all adrenergic receptors except
  13. ______ receptors are less sensitive to epinephrine so it's initial response will Be to _______stimulation
    Alpha and Beta
  14. Alpha-1 receptors are found in
    Eyes, blood vessels, bladder, male sex organs, prostatic capsule
  15. Alpha-2 receptors are found In
    Presynaptic nerve terminals
  16. Beta-1 receptors are found in
    Primarily the heart, and kidneys
  17. Beta-2 receptors are found in
    Arterioles of the heart, lungs, skeletal muscles, bronchi, uterus, liver
  18. Alpha-1 is responsible for
    Vasoconstriction of coronary arteries and veins and decrease smooth muscle motility in the G.I. tract
  19. Alpha-2 receptors are responsible for
    Shutting down the release of norepinephrine
  20. Beta-1 receptors are responsible for
    Increase cardiac output by increasing the speed of conduction, increasing the force of contraction, and increasing the pulse rate
  21. Beta-2 receptors are responsible for
    Dilation to promote breathing, creating energy from the breakdown of that stored in fat tissue also known as lipolysis, or from providing glucose to the cells through new creation of glucose (gluconeogenesis) or the breakdown of glycogen into glucose
  22. Beta three receptors are responsible for
    help break down fats in fact issues for imaging heat and plays a major role in regulation of weight but also causes tremors that's making pharmacologically unuseful at this time
  23. Alpha-1 and beta-1 receptors response to what type of stimuli
    Epinephrine, norepinephrine, and dopamine
  24. Alpha-2 and beta-2 receptors response to what type of stimuli
    Epinephrine and norepinephrine
  25. Many dopamine receptors are located where
    In the kidneys. and in low amounts dopamine Binds with vascular and renal receptors dilating blood vessels, increasing blood flow to the renal, mesenteric, and coronary heart
  26. As dopamine increases, beta-1 receptors are stimulated. Dopamine in highest concentrations act on alpha-1 receptors.
  27. There are 5 types of dopamine receptors and only two mediate responses in the Adrenergic nervous system, what are those two?
    Dopamine one and dopamine two
  28. Stimulation of dopamine one and dopamine two receptors results in ________ ;however stimulating both receptors may have either complementary or opposing effects
    Peripheral vasodilation
  29. _________ Is a dopamine one agonist in the prototype for dopaminergic agonist drugs
  30. Fenoldopam is use in the hospital for short-term management of what disease
    Severe hypertension
  31. Fenoldopam is contradicted in patients with what issues
    Hypersensitivity to sulfites, history of glaucoma or intraocular hypertension, Hypokalemia because fenoldopam may reduce serum potassium with administrative for more than six hours. Also is given cautiously in the patients with acute cerebral infarction or hemorrhage just because it may call hypotension
  32. When giving Fenoldapam
    Should be diluted with sodium chloride or dextrose, titrated, and monitored closely
  33. Prazosin is used to treat what diseases
    • CHF
    • Raynaud vasospasms
    • prostatic outflow obstruction
  34. Prazosin blocks postsynaptic alpha-1 adrenergic recepotrs and lowers what two blood pressures
    supine and standing
  35. You should not use Prazosin in what contrindicated populations
    • Hypersensitivy
    • pts. with angina because hypotension may worsen the condition
    • CHF or renal failure
  36. Light headedness, dizziness, headache, drowsiness, weakness, lethargy, nausea, and palpitations are all adverse effects of what drug.
  37. Symptomatic hypotension, tachycardia, adbominal or back pain, GI effects, sweating, and CNS effects such as insomnia, dizziness, nervousness, or anxiety are all adverse efeects of _______________
  38. ___________ is used for the treatment of hypertensio, angina, and controlled CHF
  39. Pharmacodynamics of Metoporol is?
    decreases cardiac output, blood pressure, and slows atrioventricular conduction and suppression of automaticity
  40. enteral route uses _______ for the ingestion and absorption of drugs.
    GI tract
  41. Parenteral route, which includes topical as a sub classification, distrubutes drugs how?
    By bypassing the GI tract in forms of injections and topical appliance to skin or mucous membranes
  42. Most drug absortption occurs where?
    small intestines
  43. Desired therapeutic effect of the drug is called?
  44. what is phatmacokinetics?
    the changes that occur to the drug while it is inside the body
  45. Pharmacodynamics is _____________
    the effects of the drug on the body
  46. What are effects that may occur when the drug is given along with another drug, food, or substance?
    drug interactions
  47. Core patient variables are:
    • health status
    • life span and gender
    • lifestyle, diet, and habits
    • environment
    • culture and inherited traits
  48. Pre clincal trials are designed
    to provide basic safety, bioavailability, pharmacokinetic, and intial efficay data about the drug and are carried out in animal subjects in the laboratory setting